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16 S acetylcholinesterase in endplate-free regions of developing rat diaphragm

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Abstract

Velocity sedimentation patterns of acetylcholinesterase (AChE, EC 3.7.1.1) in endplate-free regions of the diaphragm were studied in rats during early postnatal development. A significant amount of 16 S AChE, comprising 20% total activity, was found in endplate-free regions of the diaphragm of 8- and 19-day-old rats. By 32 days after birth, 16 S AChE accounted for less than 5% total AChE activity in endplate-free regions. 16 S AChE is, therefore, not strictly an endplate-specific molecular form. Instead, it becomes restricted to the motor endplate region of the rat diaphragm by the end of the first month of life.

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  1. Institute of Pathophysiology, Medical School, 61105, Ljubljana, Yugoslavia

    Janez Sketelj & Miro Brzin

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  1. Janez Sketelj
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  2. Miro Brzin
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Sketelj, J., Brzin, M. 16 S acetylcholinesterase in endplate-free regions of developing rat diaphragm. Neurochem Res 5, 653–658 (1980). https://doi.org/10.1007/BF00964786

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