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Integration of canine proximal gastric, antral, pyloric, and proximal duodenal motility during fasting and after a liquid meal

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Abstract

The aim was to investigate the integration of proximal gastric, antral, pyloric, and duodenal motility during fasting and after feeding. Using a proximal gastric barostat and a manometric assembly with an array of side holes astride the gastroduodenal junction, the gastrointestinal interdigestive migrating motor complex was detected in five of seven conscious fasting dogs. During phase III of the complex, which lasted a mean ± SEM of 13 ± 0.5 min, 9.6 ± 0.9 volume waves were present in the proximal stomach. The volume waves were coordinated with clusters of antral waves 64 ± 11% of the time and with inhibition of duodenal waves 91±3% of the time. A 300-ml calorie-dense liquid meal abolished the complex and promptly increased proximal gastric volume in five of six dogs. Volume waves were nearly completely suppressed, while antral waves decreased from 24 ±3.0 waves/10 min to 10±2.8 waves/10 min (P<0.05) and isolated pyloric pressure waves increased from 7.2±2.8 waves/10 min to 22±3.3 waves/10 min (P<0.005). In summary, proximal gastric motility was integrated with antral, pyloric, and duodenal motility under both fasting and fed conditions. The integrated patterns likely account for the efficient clearance of indigestible solids during fasting and the controlled emptying of nutrients with feeding.

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Authors and Affiliations

  1. Department of Surgery, Mayo Clinic and Mayo Foundation, 55905, Rochester, Minnesota

    Richard Heddle MBBS, Brent W. Miedema MD &  Keith A. Kelly MD

  2. Digestive Disease Center, Mayo Clinic and Mayo Foundation, 200 First Street S. W., 55905, Rochester, Minnesota

    Richard Heddle MBBS, Brent W. Miedema MD &  Keith A. Kelly MD

Authors
  1. Richard Heddle MBBS
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  2. Brent W. Miedema MD
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  3. Keith A. Kelly MD
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Additional information

Supported in part by USPHS NIH Grants DK 18278, DK34988, and DK07198, the Winthrop Travelling Fellowship of the Royal Australasian College of Physicians, the S.K.F. (Australia) Travelling Fellowship, and the Mayo Foundation.

This work was presented in part before the World Congress of Gastroenterology, Sydney, Australia, August 30, 1990

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Heddle, R., Miedema, B.W. & Kelly, K.A. Integration of canine proximal gastric, antral, pyloric, and proximal duodenal motility during fasting and after a liquid meal. Digest Dis Sci 38, 856–869 (1993). https://doi.org/10.1007/BF01295912

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  • DOI: https://doi.org/10.1007/BF01295912

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