Abstract
The aim was to investigate the integration of proximal gastric, antral, pyloric, and duodenal motility during fasting and after feeding. Using a proximal gastric barostat and a manometric assembly with an array of side holes astride the gastroduodenal junction, the gastrointestinal interdigestive migrating motor complex was detected in five of seven conscious fasting dogs. During phase III of the complex, which lasted a mean ± SEM of 13 ± 0.5 min, 9.6 ± 0.9 volume waves were present in the proximal stomach. The volume waves were coordinated with clusters of antral waves 64 ± 11% of the time and with inhibition of duodenal waves 91±3% of the time. A 300-ml calorie-dense liquid meal abolished the complex and promptly increased proximal gastric volume in five of six dogs. Volume waves were nearly completely suppressed, while antral waves decreased from 24 ±3.0 waves/10 min to 10±2.8 waves/10 min (P<0.05) and isolated pyloric pressure waves increased from 7.2±2.8 waves/10 min to 22±3.3 waves/10 min (P<0.005). In summary, proximal gastric motility was integrated with antral, pyloric, and duodenal motility under both fasting and fed conditions. The integrated patterns likely account for the efficient clearance of indigestible solids during fasting and the controlled emptying of nutrients with feeding.
Similar content being viewed by others
References
Azpiroz F, Malagelada J-R. Physiological variations in canine gastric tone measured by an electronic barostat. Am J Physiol 248:G229-G237, 1985
Azpiroz F, Malagelada J-R: Intestinal control of gastric tone. Am J Physiol 249:G501-G509 1985
Heddle R, Collins PJ, Dent J, Horowitz M, Read NW, Chatterton B, Houghton LA: The motor mechanisms associated with slowing of the gastric emptying of a solid meal by an intraduodenal lipid infusion. J Gastroenterol Hepatol 4:437–447, 1989
Heddle R, Dent J, Toouli J, Read NW: Topography and measurement of pyloric pressure waves and tone in humans. Am J Physiol 225:G490-G497, 1988
Heddle R, Fone D, Dent J, Horowitz M: Stimulation of pyloric motility by intraduodenal dextrose in normal subjects. Gut 29:1349–1357, 1988
Hougton LA, Read NW, Heddle R, Maddern GJ, Downton J, Toouli J, Dent J: Motor activity of the gastric antrum, pylorus, and duodenum under fasted conditions and after a liquid meal. Gastroenterology 94:1276–1284, 1988
Mroz CT, Kelly KA: The role of the extrinsic antral nerves in the regulation of gastric emptying. Surg Gynecol Obstet 145:369–377, 1977
Azpiroz F, Malagelada J-R: Pressure activity patterns in the canine proximal stomachs: Response to distention. Am J Physiol 247:G265-G272, 1984
White CM, Poxon V, Alexander-Williams J: Effects of nutrient liquids on human gastroduodenal motor activity. Gut 24:1109–1116, 1983
Houghton LA, Read NW, Heddle R, Horowitz M, Collins PJ, Chatterton B, Dent J: Relationship of the motor activity of the antrum, pylorus, and duodenum to gastric emptying of a solid-liquid mixed meal. Gastroenterology 94:1285–1291, 1988
Tougas G, Anvari M, Dent J, Somers S, Richards D, Stevenson GW: Relation of pyloric motility to pyloric opening and closure in healthy subjects. Gut 3:466–471, 1992
Collins PJ, Houghton LA, Read NW, Horowitz M, Chatterton BE, Heddle R, Dent J: Role of the proximal and distal stomach in mixed solid and liquid meal emptying. Gut 32:615–619, 1991
Carlson HC, Code CF, Nelson RA: Motor action of the canine gastroduodenal junction: A cineradiographic, pressure and electric study. Am J Dig Dis 11:155–171, 1966
Ehrlein H-J, Hiesinger E: Computer analysis of mechanical activity of gastroduodenal junction in unanesthetized dogs. Q J Exp Physiol 67:17–29, 1982
Kumar D, Ritman EL, Malagelada J-R: Three-dimensional imaging of the stomach: Role of the pylorus in the emptying of liquids. Am J Physiol 253:G79-G85, 1987
Keinke O, Ehrlein H-J: Effect of oleic acid on canine gastroduodenal motility, pyloric diameter, and gastric emptying. Q J Exp Physiol 68:675–686, 1983
Mir SS, Mason GR, Ormsbee HS: An inhibitory innervation at the gastroduodenal junctions in anesthetized dogs. Gastroenterology 73:432–434, 1977
Allescher HD, Daniel EE, Dent J, Fox JET, Kostolanska F: Extrinsic and intrinsic neural control of pyloric sphincter pressure in the dog. J Physiol 401:17–38, 1988
Hydén S: A turbidimetric method for the determination of higher polyethylene glycols in biological materials. K Lantbrukshoegskol Ann 22:139–145, 1956
Ehrlein H-J: Motility of the pyloric sphincter studied by the inductograph method in conscious dogs. Am J Physiol 254:G650-G657, 1988
Defilippi CC, Gomez E: Continuous recording of pyloric sphincter pressure in dogs. Relationship to migratory motor complex. Dig Dis Sci 30:669–674, 1985
Telford GL, Mir SS, Mason GR, Ormsbee HS: Neural control of the canine pylorus. Am J Surg 137:92–98, 1979
Clarke RT, Alexander-Williams J: The effect of preserving antral innervation and of a pyloroplasty on gastric emptying after vagotomy in man. Gut 14:300–307, 1973
White CM, Poxon V, Alexander-Williams J: The importance of the distal stomach in gastric emptying of liquids in man. Surg Gastroenterol 3:13–20, 1984
Fone DR, Horowitz M, Dent J, Read NW, Heddle R: The pyloric motor responses to intraduodenal dextrose involves muscarinic mechanisms. Gastroenterology 97:83–90, 1989
Cannon WB: The movements of the stomach studied by means of the Röntgen rays. Am J Physiol 1:359–382, 1898
Weisbrodt NW, Wiley JN, Overholt BF, Bass P: A relation between gastroduodenal muscle contractions and gastric emptying. Gut 10:543–548, 1969
Borgström S, Arborelius M: The significance of motility for acid base regulation of the duodenal bulb. Scand J Gastroenterol 10(suppl 35):80–82, 1975
Dalton RR, Zinsmeister AR, Sarr MG: Vagus-dependent disruption of interdigestive canine motility by gastric distention. Am J Physiol 262:G1097-G1103, 1992
Parr NJ, Grime JS, Baster JN, Critchley M, Mackie CR: Small bowel resistances and the gastroduodenal brake. Gut 28:950–954, 1987
Miller J, Kauffman G, Elashoff J, Ohashi H, Carter D, Meyer JH: Search for resistances controlling canine gastric emptying of liquid meals. Am J Physiol 241:G403-G415, 1981
Fone DR, Horowitz M, Heddle R, Maddox AF, Collins PJ, Read NW, Dent J: Comparative effects of duodenal and ileal intubation on gastric emptying and postprandial antral, pyloric and duodenal motility. Scand J Gastroenterol 26:16–22, 1991
Author information
Authors and Affiliations
Additional information
Supported in part by USPHS NIH Grants DK 18278, DK34988, and DK07198, the Winthrop Travelling Fellowship of the Royal Australasian College of Physicians, the S.K.F. (Australia) Travelling Fellowship, and the Mayo Foundation.
This work was presented in part before the World Congress of Gastroenterology, Sydney, Australia, August 30, 1990
Rights and permissions
About this article
Cite this article
Heddle, R., Miedema, B.W. & Kelly, K.A. Integration of canine proximal gastric, antral, pyloric, and proximal duodenal motility during fasting and after a liquid meal. Digest Dis Sci 38, 856–869 (1993). https://doi.org/10.1007/BF01295912
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01295912