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Gastric protection by meciadanol

A new synthetic flavonoid-inhibiting histidine decarboxylase

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Abstract

Flavonoids reportedly inhibit histidine decarboxylase and reduce gastric mucosal histamine content. We studied the effects of acute and chronic intragastric administration to rats of meciadanol, a new synthetic flavonoid (Zyma S.A., Nyon, Switzerland). The action of meciadanol was compared to that of 16, 16-dimethyl PGE2. Meciadanol did not affect acid or pepsin output at any dose used. High doses of 16, 16-dimethyl PGE2 reduced both acid and pepsin output. Meciadanol partially prevented aspirin-induced lesions but the prevention required chronic administration of meciadanol. In contrast, a single dose of meciadanol completely prevented ethanol-induced lesions. Chronic administration of meciadanol also completely prevented ethanol-induced lesions. 16, 16-Dimethyl PGE2 prevented both aspirin-induced and ethanol-induced lesions in doses that did not affect acid or pepsin output. Meciadanol did not influence the effect that either aspirin or ethanol had on endogenous mucosal PGI2. Thus, the dose range of meciadanol that protected against ulcerogens did not affect either gastric acid secretion or pepsin output. Therefore, we conclude that meciadanol's action represents true cytoprotection, which was previously attributed only to prostaglandins.

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Authors and Affiliations

  1. Institute of Physiology, Academy of Medicine, Grzegorzecka 16, 31-531, Krakow, Poland

    Stanislaw J. Konturek, Mary Ellen Kitler, Tomasz Brzozowski & Tadeusz Radecki

  2. Experimental Therapeutics, Zyma S.A., Nyon, Switzerland

    Stanislaw J. Konturek, Mary Ellen Kitler, Tomasz Brzozowski & Tadeusz Radecki

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  1. Stanislaw J. Konturek
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  2. Mary Ellen Kitler
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  3. Tomasz Brzozowski
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  4. Tadeusz Radecki
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Konturek, S.J., Ellen Kitler, M., Brzozowski, T. et al. Gastric protection by meciadanol. Digest Dis Sci 31, 847–852 (1986). https://doi.org/10.1007/BF01296054

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  • DOI: https://doi.org/10.1007/BF01296054

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