Abstract
The penetration of ceftriaxone and cefoperazone into bile and gallbladder tissue was prospectively studied in 21 adult patients undergoing early surgery for acute cholecystitis. Comparable tissue, bile, and serum concentrations of the drugs were demonstrable; however, significantly fewer preoperative doses of ceftriaxone were required for adequate perioperative treatment. In view of its higher serum half-life and superior antibacterial activity toward common biliary pathogens, ceftriaxone appears to be a useful drug for the perioperative management of acute cholecystitis.
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Berger SA, Levy Y, Halevy A, Gorea A, Orda R: Penetration of cefazolin, ceftriaxone, cefoperazone and ceftazidime into human gallbladder tissue and bile. World J Surg 12:641–644, 1988
Ratzan KR, Baker HB, Lauredo I: Excretion of cefamandole, cefazolin, and cephalothin into T-tube bile. Antimicrob Agents Chemother 13:985–987, 1978
Hayton WL, Schandlik R, Stoeckel K: Biliary excretion and pharmacokinetics of ceftriaxone after cholecystectomy. Eur J Clin Pharmacol 30:445–451, 1986
Nakamura T, Hashimoto I, Sawada Y, Mikami J, Bekki E, Hirasawa S, Abe H, Watanabe Y: Cefoperazone concentrations in bile and gallbladder wall after intravenous administration. Antimicrob Agents Chemother 18:980–982, 1980
Richards DM, Heel RC, Brogden TM, Speight T, Avery GS: Ceftriaxone: A review of its antibacterial activity, pharmacological properties and therapeutic use. Drugs 27:469–527, 1984
Arvidsson A, Alvan G, Angelin B, Borga O, Nord CE: Ceftriaxone: Renal and biliary excretion and effect on the colon microflora. J Antimicrob Chemother 10:207–215, 1982
Maugdal DP, Maxwell JD, Lees LJ, Wild RN: Biliary excretion of amoxycillin and ceftriaxone after intravenous administration in man. Br J Clin Pharmacol 14:213–217, 1982
Kemmerich B, Lode H, Borner K, Belmega D, Jenderoschek T, Koeppe P, Goertz G: Biliary excretion and pharmacodynamics of cefoperazone in humans. J Antimicrob Chemother 12:27–37, 1983
Wright WE, Line VD: Biliary excretion of cephalosporins in rats: Influence of molecular weight. Antimicrob Agents Chemother 17:842–847, 1980
Rollins DE: Pharmacokinetics and drug excretion in bile.In Pharmacokinetic Basis for Drug Treatment. LZ Benet, N Massoud, JG Gambertoglio (eds). New York, Raven Press, 1984, pp 77–88
Strange RC: Hepatic bile flow. Physiol Rev 64:1055–1102, 1984
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Orda, R., Berger, S.A., Levy, Y. et al. Penetration of ceftriaxone and cefoperazone into bile and gallbladder tissue in patients with acute cholecystitis. Digest Dis Sci 37, 1691–1693 (1992). https://doi.org/10.1007/BF01299860
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DOI: https://doi.org/10.1007/BF01299860