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Local blood flow changes in malignant brain tumours under induced hypertension

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Summary

Changes in tumour blood flow under an induced hypertensive state were examined in malignant brain tumours to know if the precondition for the effectiveness of induced hypertensive chemotherapy — relative increase in tumour blood flow — are fulfilled. Tumour blood flow was measured under both a resting and an induced hypertensive state in 12 patients with various malignant brain tumours (6 gliomas, 6 metastatic brain tumours) using xenon-enhanced computed tomography. The blood pressure was elevated 40% above the systemic blood pressure of the resting state by the infusion of angiotensin II. Tumour blood flow increased 30% on average above the normal brain tissue blood flow after the induction of an induced hypertensive state (p < 0.05). The tumour blood flow increased in 11 cases of malignant tumours, but decreased in one case with massive brain oedema after induced hypertension. The increase in blood flow was higher in hypervascular tumours and less in hypovascular tumours. Therefore, induced hypertensive chemotherapy probably will be more effective in hypervascular malignant brain tumours with small mass effects.

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References

  1. Arbit E, DiResta GR, Bedford RF, Shah NK, Galicich JH (1989) Intraoperative measurement of cerebral and tumour blood flow with Laser-Doppler flowmetry. Neurosurgery 24: 166–170

    PubMed  Google Scholar 

  2. Heindel W, Bunke J, Glathe S, Steinbrich W, Mollevanger J (1988) Combined 1H-MR imaging and localized 31P-spectroscopy of intracranial tumours in 43 patients. J Comput Assist Tomogr 12: 907–916

    PubMed  Google Scholar 

  3. Kety SS, Schmidt CF (1948) The nitrous oxide method for the quantitative determination of cerebral blood flow in man: theory, procedure and normal values. J Clin Invest 27: 476–483

    Google Scholar 

  4. Kontos HA, Wei EP, Navari RM, Levasseur JE, Rosenblum WI, Patterson JL Jr (1977) Responses of cerebral arteries and arterioles to acute hypotension and hypertension. Am J Physiol 234: 371–383

    Google Scholar 

  5. Kontos HA, Wei EP, Navari RM, Patterson JL Jr (1978) Role of tissue hypoxia in local regulation of cerebral microcirculation. Am J Physiol 234: H582-H591

    PubMed  Google Scholar 

  6. Loew F, Papavero L (1988) The intraarterial route of drug delivery in the chemotherapy of malignant brain tumours. In: Symon Let al (eds) Advances and technical standards in neurosurgery, Vol 16. Springer, Wien New York, pp 51–79

    Google Scholar 

  7. Matsuura H, Ikeda I, Imaya H, Nakazawa S (1987) Selective changes of blood flow in experimental brain tumour with induced hypertension. Surg Neurol 27: 433–436

    PubMed  Google Scholar 

  8. Nakamura Y, Hyotani G, Terada T, Miyamoto K, Tsuura M, Nishiguchi T, Itakura T, Hayashi S, Komai N (1991) Regional cerebral blood flow measurement by stable xenon-enhanced CT-Principle and methodology. J Wakayama Med Soc 42 (2): 291–296

    Google Scholar 

  9. Sadoshima S, Heistad D, Thames MD (1981) Cerebral blood flow during alternation of intracranial pressure: effects of sympathetic nerves. Am J Physiol 241: H78-H84

    PubMed  Google Scholar 

  10. Scherer HJ (1938) Structural development in gliomas. Am J Cancer 14: 333–351

    Google Scholar 

  11. Suzuki M, Hori K, Abe I, Saito S, Sato H (1981) A new approach to cancer chemotherapy: selective enhancement of tumour blood flow with angiotensin II. JNCl 67: 663–669

    Google Scholar 

  12. Takakura K, Abe H, Tanaka R, Kitamura K, Miwa T, Takeuchi K, Yamamoto S, Kageyama N, Handa H, Mogami H, Nishimoto A, Uozumi T, Matsutani M, Nomura K (1986) Effect of ACNU and radiation therapy on malignant glioma. J Neurosurg 64: 53–57

    PubMed  Google Scholar 

  13. Walker MD, Alexander E Jr, Hunt WE, MacCarty CS Jr, Mahaley MS, Mealey J Jr, Norrell HA, Owens G, Ransohoff J, Wilson CB, Gehan EA, Strike TA (1978) Evaluation of BCNU and/or radiotherapy in the treatment anaplastic gliomas. A cooperative clinical trial. J Neurosurg 49: 333–343

    PubMed  Google Scholar 

  14. Yonas H, Good WF, Gur D, Wolfson SK, Latchaw RE, Good BC, Leanza R, Miller SL (1984) Mapping cerebral blood flow by xenon-enhanced computed tomography: clinical experience. Radiology 152: 435–442

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Neurological Surgery, Wakayama Medical College, Wakayama City, Japan

    T. Terada, K. Miyamoto, G. Hyotani, M. Tsuura, Y. Nakamura, T. Nishiguchi, T. Itakura, S. Hayashi & N. Komai

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  1. T. Terada
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  2. K. Miyamoto
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  3. G. Hyotani
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  4. M. Tsuura
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  5. Y. Nakamura
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  6. T. Nishiguchi
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  7. T. Itakura
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  8. S. Hayashi
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  9. N. Komai
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Terada, T., Miyamoto, K., Hyotani, G. et al. Local blood flow changes in malignant brain tumours under induced hypertension. Acta neurochir 118, 108–111 (1992). https://doi.org/10.1007/BF01401295

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  • DOI: https://doi.org/10.1007/BF01401295

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