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Gliomatosis cerebri: Bioptical approach and neuropathological verification

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Summary

Gliomatosis cerebri is rarely encountered and itsintra vitam diagnosis has remained difficult. We present biopsy and autopsy findings in three cases that are representative of diffuse glioma, gliomatosis cerebri and diffuse glioblastosis, a modification of the subclassification proposed by Zülch. Stereotactic biopsy in conjunction with nuclear magnetic resonance tomography (MRT) is recommended as the diagnostic procedure in suspected cases. Immunohistochemical examination with a panel of neuroectodermal markers is helpful in the differential diagnosis but has to take into account that reactive astrocytes may be closely intermingled with the neoplastic glial cells.

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Authors and Affiliations

  1. Departments of Neuropathology, Heinrich-Heine-University, Düsseldorf

    R. Schober & W. Wechsler

  2. Departments of Neuroanatomy, Heinrich-Heine-University, Düsseldorf

    J. K. Mai

  3. Department of Neuropathology, University of Freiburg, Germany

    B. Volk

Authors
  1. R. Schober
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  2. J. K. Mai
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  3. B. Volk
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  4. W. Wechsler
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Schober, R., Mai, J.K., Volk, B. et al. Gliomatosis cerebri: Bioptical approach and neuropathological verification. Acta neurochir 113, 131–137 (1991). https://doi.org/10.1007/BF01403198

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