Summary
The coagulation profile of 25 patients with brain tumours was studied preoperatively, intraoperatively and postoperatively. Ten patients had abnormal coagulation status preoperatively. Surgical intervention led to either an alteration of preexisting abnormality or appearance of new coagulation abnormality. Disseminated intravascular coagulation and fibrinolysis occurred with equal frequency in patients with meningiomas and gliomas. The alterations as a result of surgery were transient and compensated rapidly.
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References
Auer L (1978) Disturbances in coagulatory system in patients with severe cerebral trauma I. Acta Naurochir (Wien) 43: 51–59
Auer L, Ott E (1978) Disturbances of the coagulatory system in patients with severe cerebral trauma II. Acta Neurochir (Wien) 49: 219–226
Bjorkild E, Storm-Mathisen J, Storm E, Prydz H (1977) Localization of tissue thromboplastin in human brain. Thromb Haemost 37: 92–97
Dacie JV, Lewis SM (1984) Practical haematology. Sixth Edition. Churchill Livingstone. Edinburgh London Melbourne and New York
Edwards EA (1949) Migratory thrombophlebitis associated with carcinoma. N Eng J Med 240: 1031–1035
Hagedorn AB, Bowie EJW, Elveback LR, Owens Junior CA (1974) Coagulation abnormalities in patients with inoperable lung cancer. Mayo Clin Proc 49: 647–653
Ingram GIC, Brozovic M, Slater NGP (1982) Bleeding disorders. Second edition. Blackwell Scientific Publications
Kayser-Gatchalian MC, Kayser K (1975) Thrombosis and intracranial tumours. J Neurol 209: 217–224
MacGee EE, Bernell WR (1970) Acute fibrinolysis following craniotomy and removal of metastatic tumour of the cerebellum. J Neurosurg 32: 578–580
Matjasha MJ, Ducker TB (1977) Disseminated intravascular coagulation associated with removal of a primary tumour. J Neurosurg 47: 476–480
Mattock C, Crockard A (1986) Does intravascular coagulation contribute to operative mortality for large acoustic tumours. J Neurol Neursourg Psychiatry 49: 699–671
Miner ME, Kaufman HH, Graham SH, Haar F, Gildenberg PL (1982) Disseminated intravascular coagulation and fibrinolytic syndrome following head injury in children: Frequency and prognostic implications. J Pediatr 100: 687–691
Ruff RL, Posner JB (1983) Incidence and treatment of peripheral venous thrombosis in patients with gliomas. Ann Neurol 13: 334–336
Sawaya R, Cummins CJ, Kornblith PL (1984) Brain tumours and plasmin inhibitors. Neurosurgery 15: 795–800
Sawaya R, Kornblith PL (1987) Brain tumours and thromboembolic complications. Surg Neurol 28: 163
Sproul EE (1938) Carcinoma and venous thrombosis: frequency of association of carcinoma in body or tail of pancreas with multiple venous thrombosis. Am J Cancer 34: 566–585
Takashima S, Koya M, Tanaka K (1969) Fibrinolytic activity of human brian and CSF. BR J Exp Pathol 50: 533–539
Tovi D (1973) Fibrinolytic activity of human brain. Acta Neurol (Napoli) 49: 152–162
Tovi D, Pandolfi M, Astedt B (1975) Local haemostasis in brain tumours. Experientia 31: 977–978
Trousseau A (1865) Phlegmasia alba dolens. In: Clinique Medicale de l'Hotel-Dieu de Paris, vol 3. pg 654, second edition. Balliere, Paris. Cited by Edwards EA-reference 3
Van der Sande JJ, Veltkamp JJ, Boekhavt-Mussert RJ, Bouwhuis-Hoogerwerf ML (1978) Head injury and coagulation disorders. J Neurosurg 49: 357–365
Vardi Y, Steifler M, Schujman E, Lowenthal M (1974) Diffuse intravascular coagulation associated with a primary brain tumour. J Neurol Neurosurg Psychiatry 37: 987–990
Vecht CJ, Smit Sibinga CT, Minderhoud JM (1975) Disseminated intravascular coagulation and head injury. J Neurol Neurosurg Psychiatry 38: 567–571
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Singh, V.P., Jain, D., Mohan, R. et al. Haemostatic abnormalities in brain tumours. Acta neurochir 102, 103–107 (1990). https://doi.org/10.1007/BF01405422
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DOI: https://doi.org/10.1007/BF01405422