Summary
The diffusion of four steroids across a cellulose acetate membrane has been examined and from the variation of diffusion rate with temperature the energies of activation have been estimated. The energies of activation are compared with solubility and partition data and it suggested the relative hydrogen bonding ability of the four steroids is of considerable importance in governing the diffusion rate.
Similar content being viewed by others
References
Short, P. M., E. T. Abbs, andC. T. Rhodes, J. Pharm. Sci.59, 995 (1970).
Frisch, H. L., Polymer Letters3, 13 (1965).
Barrer, R. M., J. Phys. Chem.61, 178 (1957).
British Pharmacopoeia, Pharmaceutical Press (London 1963).
Tuwiner, S. B., Diffusion and membrane technology Chapman and Hall Ltd. (London 1962).
Chemburkar, P. B., Ph. D. thesis, University of Florida (1967).
Bries, M. J. andJ. H. Smit, J. South Af. Chem. Inst.22, 128 (1969).
Diamond, J. M. andE. M. Wright, Proc. Roy. Soc.172, 273 (1969).
Friedman, S., S. S. Koide, andF. A. Kincl, Steroids15, 679 (1970).
Scheuplein, R. J., I. H. Blank, G. J. Brauner, andD. J. Macfarlane. J. Invest. Dermatology52, 63 (1969).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Short, M.P., Rhodes, C.T. Some studies of the diffusion of steroids across a cellulose acetate membrane. Kolloid-Z.u.Z.Polymere 250, 602–604 (1972). https://doi.org/10.1007/BF01501471
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF01501471