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Effects of nonsteroidal, antiinflammatory drugs on gastrointestinal injury and prostanoid generation in healthy volunteers

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Abstract

A new nonsteroidal, antiinflammatory drug, carprofen, was compared with indomethacin as to their effects on mucosal injury and prostanoid biosynthesis. A prospective, double-blind endoscopy study was performed in 40 healthy adults. After baseline normal endoscopy, 20 subjects were randomly assigned to either indomethacin (25 mg four timesdaily) or carprofen (150 mg twice daily) for eight days and reendoscoped. Urinary and gastric mucosal prostaglandin generation, respectively, of PGE2 and PGE2α, and PGE and 6-keto-PGE1α was determined. Minor subjective symptoms occurred in six of 20 indomethacin (including four of eight with gastrointestinal injury) and in three of 20 carprofen subjects. Indomethacin and carprofen reduced gastric and urinary prostaglandin synthesis to a similar degree. Gastrointestinal injury was present in eight of20 indomethacin and in none of 20 carprofen subjects. This study fails to establish a relationship between duodenal mucosal lesions and gastric prostanoid generation and confirms the lack of correlation between indomethacin-induced duodenal injury and subjective symptomatology. Carprofen appears to produceless objective damage in the upper gastrointestinal tract than indomethacin at comparable clinical doses.

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Authors and Affiliations

  1. Department of Medicine, State University of New York Health Science Center, Syracuse, New York

    Robert A. Levine MD, Susan Petokas MSN, Jyotirmoy Nandi PhD & Dirk Enthoven MD

  2. Department of Clinical Investigation, Hoffmann-La Roche Inc., Nutley, New Jersey

    Robert A. Levine MD, Susan Petokas MSN, Jyotirmoy Nandi PhD & Dirk Enthoven MD

Authors
  1. Robert A. Levine MD
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  2. Susan Petokas MSN
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  3. Jyotirmoy Nandi PhD
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  4. Dirk Enthoven MD
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Levine, R.A., Petokas, S., Nandi, J. et al. Effects of nonsteroidal, antiinflammatory drugs on gastrointestinal injury and prostanoid generation in healthy volunteers. Digest Dis Sci 33, 660–666 (1988). https://doi.org/10.1007/BF01540427

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  • DOI: https://doi.org/10.1007/BF01540427

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