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Biotin. Its place in evolution

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Summary

In the previous article we try to give an explanation for the success of models for enzymatic reactions in which coenzymes play a role. However, one vital cofactor that has thus far not yielded appreciably to this approach is biotin. We attempt to show that biotin presents a fundamentally new sort of problem to bioorganic chemistry; this problem requires consideration both of the origin of life and subsequent evolution in any attempt to understand the anomalies offered by this cofactor.

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Visser, C.M., Kellogg, R.M. Biotin. Its place in evolution. J Mol Evol 11, 171–187 (1978). https://doi.org/10.1007/BF01733892

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