Abstract
DNA regions of chromosomes that are replicated during zygotene are not ligated to the body of nuclear DNA on completion of replication. The discontinuities are present only in the strands that are synthesized during premeiotic S and they persist through prophase until the interval of chromosome disjunction. The discontinuities are gaps rather than nicks, and must be shielded in vivo from repair activity during pachytene when gaps elsewhere in the DNA are being repaired. The gaps can nevertheless be cured in isolated prophase nuclei in the presence of added polymerase and ligase.
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Hotta, Y., Stern, H. Persistent discontinuities in late replicating DNA during meiosis inLilium . Chromosoma 55, 171–182 (1976). https://doi.org/10.1007/BF01798347
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DOI: https://doi.org/10.1007/BF01798347