Abstract
There is a well-recognized relationship between autonomic nervous system function and body habitus although few studies have addressed the role of the parasympathetic nervous system. A decrease in parasympathetic nervous-system-mediated heart rate variability in obesity may in part explain the mortality and morbidity that are associated with the obese state. We used multiple linear regression techniques to explore the relationship between measures of heart rate variability and anthropometric indices in 597 male participants in the Normative Aging Study. After adjustment for age and log10 heart rate, weight and body mass index were significant predictors of both the expiratory to inspiratory ratio (E/I ratio) and the difference between maximum and minimum heart rate (HRMax-Min). The abdomen-to-hip ratio and percentage body fat were not significant predictors of measures of heart rate variability. A one standard deviation change in the anthropometric index (weight, body mass index) resulted in a decrease in the E/I ratio of 0.010–0.014 and a decrease in the HRMax-Min of 0.486–0.715 beats/min. A change in the anthropometric index across the distribution (5–95 percentile) resulted in a decrease in the E/I ratio of 0.032–0.037 and a decrease in the HRMax-Min of 1.56–2.39 beats/min. These results indicate that heart rate variability and overall body size are correlated. This association could in part explain the mortality and morbidity that is associated with the obese state.
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Bray GA. Integration of energy intake and expenditure in animals and man: the autonomic and adrenal hypothesis.Endocrinol Metab 1984;13: 521–546.
Bray GA. Autonomic and endocrine factors in the regulation of energy balance.Fed Proc 1986;45: 1404–1410.
Landsberg L, Young JB. Fasting, feeding and regulation of the sympathetic nervous system.N Engl J Med 1978;298: 1295–1301.
Young JB, Landsberg L. Suppression of sympathetic nervous system during fasting.Science 1977;196: 1473–1475.
Bryant KR, Rothwell NJ, Stock MJ, Wyllie MG. Parasympathetic effects on diet-induced thermogenesis.Eur J Pharmacol 1983;95: 291–294.
Nacht CA, Cristin L, Temler E, Chiolero R, Jequier E, Acheson KJ. Thermic effect of food: possible implication of parasympathetic nervous system.Am J Physiol 1987;253: E481-E488.
Peterson HR, Rothschild M, Weinberg CR, Fell RD, McLeish KR, Pfeifer MA. Body fat and the activity of the autonomic nervous system.N Engl J Med 1988;318: 1077–1083.
Rossi M, Marti G, Ricordi Let al. Cardiac autonomic dysfunction in obese subjects.Clin Sci 1989;76: 567–572.
Hirsch J, Leibel RL, Mackintosh R, Aguirre A. Heart rate variability as a measure of autonomic function during weight change in humans.Am J Physiol 1991;261: R1418-R1423.
Hubert HB, Feinleib M, McNamara PM, Castelli WP. Obesity as an independent risk factor for cardiovascular disease: a 26-year followup of participants in the Framingham Heart Study.Circulation 1983;67: 968–977.
Lapidus L, Bengtsson C, Larsson B, Pennert K, Rybo E, Sjostrom L. Distribution of adipose tissue and risk of cardiovascular disease and death: a 12 year follow up of participants in the population study of women in Gothenburg, Sweden.BMJ 1984;289: 1257–1261.
Larsson B, Svardsudd K, Welin L, Wilhelmsen L, Bjorntorp P, Tibblin G. Abdominal adipose tissue distribution, obesity, and risk of cardiovascular disease and death: 13 year follow up of participants in the study of men born in 1913.BMJ 1984;288: 1401–1404.
Peiris AN, Sothmann MS, Hoffmann RGet al. Adiposity, fat distribution, and cardiovascular risk.Ann Intern Med 1989;110: 867–872.
Ewing DJ, Campbell IW, Clarke BF. Assessment of cardiovascular effects in diabetic autonomic neuropathy and prognostic implications.Ann Intern Med 1980;92: 308–311.
Kleiger RE, Miller JP, Bigger JT, Jr., Moss AJ. Decreased heart rate variability and its association with increased mortality after acute myocardial infarction.Am J Cardiol 1987;59: 256–262.
Myers GA, Martin GJ, Magid NMet al. Power spectral analysis of heart rate variability in sudden cardiac death: comparison to other methods.IEEE Trans Biomed Eng 1986;33: 1149–1156.
Ewing DJ, Martyn CN, Young RJ, Clarke BF. The value of cardiovascular autonomic function tests: 10 years experience in diabetes.Diabetes Care 1985;8: 491–498.
Angelone A, Coulter NA. Respiratory sinus arrhythmia: a frequency dependent phenomenon.J Appl Physiol 1964;19: 479–482.
Wieling W, van Brederode JFM, de Rijk LG, Borst C, Dunning AJ. Reflex control of heart rate in normal subjects in relation to age: a data base for cardiac vagal neuropathy.Diabetologia 1982;22: 163–166.
Low PA, Pfeifer MA. Standardization of clinical tests for practice and clinical trials. In: Low PA, ed.Clinical Autonomic Disorders. Boston: Little, Brown and Co., 1993, 287–296.
Bell B, Rose CL, Damon H. The normative aging study: an interdisciplinary and longitudinal study of health and aging.Aging Hum Dev 1972;3: 5–17.
Young JB, Saville E, Rothwell NJ, Stock MJ, Landsberg L. Effect of diet and cold exposure on norepinephrine turnover in brown adipose tissue in the rat.J Clin Invest 1982;69: 1061–1071.
Triosi RJ, Weiss ST, Parker DR, Sparrow D, Young JB, Landsberg L. Relation of obesity and diet to sympathetic nervous system activity.Hypertension 1991;17: 669–677.
Young JB, Triosi RJ, Weiss ST, Parker DR, Sparrow D, Landsberg L. Relationship of catecholamine excretion to body size, obesity, and nutrient intake in middle-aged and elderly men.Am J Clin Nutr 1992;56: 827–834.
Young JB, Macdonald IA. Sympathoadrenal activity in human obesity: heterogeneity of findings since 1980.Int J Obes 1992;16: 959–967.
Bray GA. Obesity: a disease of nutrient or energy balance?Nutr Rev 1987;45: 33–43.
Dériaz O, Nacht CA, Choléro Ret al. The parasympathetic nervous system and the thermic effect of glucose/insulin infusions in humans.Metabolism 1989;38: 1082.
Kupari M, Virolainen J, Koskinen P, Tikkanen M. Short-term heart rate variability and factors modifying the risk of coronary artery disease in a population sample.Am J Cardiol 1994;72: 897–903.
Messerli FH, Numez BD, Ventura HO, Snyder DW. Overweight and sudden death.Arch Intern Med 1987;147; 1725–1728.
Kissebah AH, Vydelingum N, Murray Ret al. Relation of body fat distribution to metabolic complications of obesity.J Clin Endocrinol Metab 1982;54: 254–259.
Krotkiewski M, Bjorntorp P, Sjostrom L, Smith U. Impact of obesity on metabolism in men and women: importance of regional adipose tissue distribution.J Clin Invest 1983;72: 1150–1162.
Ohlson LO, Larsson B, Svardsudd Ket al. The influence of body fat distribution on the incidence of diabetes mellitus. 13.5 years of follow-up of the participants in the study of men born in 1913.Diabetes 1985;34: 1055–1058.
Modan M, Halkin H, Almog Set al. Hyperinsulinemia: a link between hypertension obesity and glucose intolerance.J Clin Invest 1985;75: 809–817.
Kaplan NM. The deadly quartet: upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension.Arch Intern Med 1989;149: 1514–1520.
Berglund G, Ljungman S, Hartford M, Wilhelmsen L, Bjorntorp P. Type of obesity and blood pressure.Hypertension 1982;4: 692–696.
Triosi RJ, Weiss ST, Segal MR, Cassano PA, Vokonas PS, Landsberg L. The relationship of body fat distribution to blood pressure in normotensive men: the normative aging study.Int J Obes 1990;14: 515–525.
Sparrow D, Borkan GA, Gerzof SG, Wisniewski C, Silbert CK. Relationship of fat distribution to glucose tolerance: results of computed tomography in male participants of the normative aging study.Diabetes 1986;35: 411–415.
Low PA, Opfer-Gehrking TL, Proper CJ, Zimmerman I. The effect of aging on cardiac autonomic and postganglionic sudomotor function.Muscle Nerve 1990;13: 152–157.
O'Brien IA, O'Hare P, Corrall RJ. Heart rate variability in healthy subjects: effect of age and the derivation of normal ranges for tests of autonomic function.Br Heart J 1986;55: 348–354.
Sowers JR, Whitfield LA, Catania RAet al. Role of the sympathetic nervous system in blood pressure maintenance in obesity.J Clin Endocrinol Metab 1982;54: 1181–1187.
Reisin E, Frohlich ED, Messerli FHet al. Cardiovascular changes after weight reduction in obesity hypertension.Ann Intern Med 1983;98: 315–319.
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Freeman, R., Weiss, S.T., Roberts, M. et al. The relationship between heart rate variability and measures of body habitus. Clinical Autonomic Research 5, 261–266 (1995). https://doi.org/10.1007/BF01818890
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DOI: https://doi.org/10.1007/BF01818890