Summary
The initial phase of pulmonary edema development following intracranial pressure elevation was studied by means of transmission electron microscopy. Using perfusion fixation and application of a blood tracer (HRP horseradish peroxidase) the time sequence and site of fluid leakage out of pulmonary vessels was demonstrated: - passage of edema fluid through intercellular clefts of alveolar capillary endothelium - edema accumulation in alveolar interstitial tissue - draining of edema fluid from the alveolar septum to the interstitium of terminal bronchioli and to lymphatic vessels. An early interepithelial fluid leakage out of the alveolar wall remains questionable.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
COTTRELL, Z.S., LEVINE, O.R., SENIOR, R.M., WIENER, J., SPIRO, D., FISHMAN, A.P.: Circulat Res.21, 783 (1967)
FISHMAN, A.P.: Discussing Simmonset al.: J. Trauma8, 800 (1968)
FISHMAN, A.P.: Ciculation46, 390 (1972)
FORSSMANN, W.G., SIEGRIST, G., ORCI, L., GIRARDIER, L., PICTET, R., ROUILLER, C.: J. Microsc. (Paris)6, 279 (1967)
GIL, J., WEIBEL, E.R.: Resp. Physiol.8, 13 (1969/70)
GRAHAM, R.C., KARNOVSKY, M.J.: J. Histochem. Cytochem.14, 291 (1966a)
GRAHAM, R.C., KARNOVSKY, M.J.: J. exp. Med.124, 1123 (1966b)
HÜCKER, H.: Verh. Dtsch. Ges. Path.57, 443 (1973)
HÜCKER, H., SCHÄFER, U., MEINEN, K.: Virchows Arch. Abt. A362, 331 (1974)
HÜCKER, H., SCHÄFER, U., MEINEN, K.: Wehrmed. Mschr.19, 84 (1975a)
HÜCKER, H., SCHÄFER, U., FRENZEL, H., KREMER, B.: Verh. dtsch. Ges. inn. Med.81, 512 (1975b)
HÜCKER, H., FRENZEL, H., SCHÄFER, U., KREMER, B.: Verh. dtsch. Ges. Path.59, 447 (1975c)
KUHN III, C., FINKE, E.H.: J. Ultrastruct. Res.38, 161 (1972)
MAIRE, F.W., PATTON, H.D.: Amer. J. Physiol.184, 351 (1956)
MEINEN, K., KREMER, B., HÜCKER, H., GEISLER, W.: Brain Res.86, 439 (1975a)
MEINEN, K., KREMER, B., WELLER, P., HÜCKER, H.: Wehrmed. Mschr.19, 68 (1975b)
OKA, K.: Jap. Circulat. J.37, 1343 (1973)
PAPPENHEIMER, J.R.: Physiol. Rev.33, 387 (1953)
PERL, W.: Microvasc. Res.3, 233 (1971)
PIETRA, G.G., SZIDON, J.P., LEVENTHAL, M.M., FISHMAN, A.P.: Science166, 1643 (1969)
PIETRA, G.G., SZIDON, J.P., LEVENTAHL, M.M., FISHMAN, A.P.: Circulat. Res.29, 323 (1971)
SCHÄFER, U., HÜCKER, H., MEINEN, K.: Res. exp. Med.165, 1 (1975a)
SCHÄFER, U., HÜCKER, H., MEINEN, K.: Wehrmed. Mschr.19, 89 (1975b)
SCHNEEBERGER-KEELEY, E.E., KARNOVSKY, M.J.: Cell Biol.37, 781 (1968)
SHIRLEY, H.H., WOLFRAM, C.G., WASSERMAN, K., MAYERSON, H.S.: Amer. J. Physiol.190, 189 (1957)
STAUB, N.C., NAGANO, H., PEARCE, M.L.: J. appl. Physiol.22, 227 (1967)
STAUB, N.C.: Amer. Rev. resp. Dis.109, 358 (1974)
SUGG, W.L., WEBB, W.R., ECKER, R.R.: Surg. Gynec. Obstet.127, 1005 (1968)
SZIDON, J.P., PIETRA, G.G., FISHMAN, A.P.: New Engl. J. Med.286, 1200 (1972)
THEODORE, J., ROBIN, E.D.: Lancet18, 749 (1975)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Hücker, H., Frenzel, H., Kremer, B. et al. Time sequence and site of fluid accumulation in experimental neurogenic pulmonary edema. Res. Exp. Med. 168, 219–227 (1976). https://doi.org/10.1007/BF01851320
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF01851320