Summary
Collateral flow to the interventricular septum in the dog was measured after septal artery ligation (N=8) and compared to that in the left ventricular free wall after occlusion of the left anterior descending coronary artery (N=10) in other animals. Flow was quantitated by radiolabelled microsphere injection before, and 90s, 2 h and 4 h after occlusion. Perfusion territory size was measured after colored dye infusion; the septal artery bed occupied 21.74±5.44% of the left ventricle and was significantly smaller than the anterior descending artery zone (40.72±5.44% of the left ventricle and was prior to occlusion was equal in both beds and symmetric across the ventricular wall; endocardial/epicardial and left/right ratios in the anterior descending and septal artery beds were 0.97±0.14 and 1.14±0.17, respectively. 90 s after occlusion, left and right septal and endocardial and epicardial anterior descending flows were significantly (p<0.05) reduced. Right septal flows exceeded left sided flows to produce a transseptal gradient. However, right septal flow was significantly greater than epicardial anterior bed values, and free wall endocardial/epicardial was significantly lower than septal left/right ratios. By 2 h after occlusion, left and right septal flows were no longer significantly different from preocclusion values, whereas anterior descending flows remained significantly below control for the full 4-h period. Thus, significant differences between the two beds exist, with greater acute collateral flows and more rapid correction of flow deficits in the septum than in the free wall.
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This research was supported by research grants from the American Heart Association. Tennessee Affiliate, from the Veterans Administration, and from the National Heart, Lung and Blood Institute (HL 20597)
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Ramanathan, K.B., Wilson, J.L. & Mirvis, D.M. Effects of coronary occlusion on transmural distribution of blood flow in the interventricular septum and left ventricular free wall. Basic Res Cardiol 83, 229–237 (1988). https://doi.org/10.1007/BF01907356
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DOI: https://doi.org/10.1007/BF01907356