Abstract
Twelve neutral free amino acids, i. e., serine, threonine, glutamine, asparagine, alanine, proline, methionine, tyrosine, valine, leucine, isoleucine and phenylalanine, were surveyed for the presence of D-enantiomers in plasma samples from patients with renal diseases and from normal subjects. D-serine, D-alanine and D-proline were found in the patient's plasma. The highest concentrations (D/L ratio) of D-serine, D-alanine and D-proline were 0.2362, 0.2087 and 0.0986, respectively. The sum of the contents of the three D-amino acids in a plasma sample correlated with the serum creatinine level of the subject. No D-amino acid was shown to be present in the plasma proteins.
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Nagata, Y., Masui, R. & Akino, T. The presence of free D-serine, D-alanine and D-proline in human plasma. Experientia 48, 986–988 (1992). https://doi.org/10.1007/BF01919147
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DOI: https://doi.org/10.1007/BF01919147