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Effect of progesterone on human corticosteroid 21-hydroxylation

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  • Endocrinologica
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Summary

Progesterone inhibits the 21-hydroxylation of 17α-hydroxyprogesterone by human adrenal cortex microsomes. The possible light this finding may shed on the genetic condition, the ‘adrenogenital syndrome’ is discussed.Km and Vmax data for the above hydroxylation reaction are given.

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Author information

Author notes

  1. R. H. Wickramasinghe

    Present address: Laboratory of Human Reproduction and Reproductive Biology, Harvard Medical School, 45 Shattuck Street, 02115, Boston, Massachusetts, USA

Authors and Affiliations

  1. Pediatric Endocrine Laboratory, Department of Pediatrics, The University of Texas Medical Branch, Galvestone, Texas, USA

    R. H. Wickramasinghe & G. T. Bryan

  2. Clinical Study Center, The University of Texas Medical Branch, Galvestone, Texas, USA

    R. H. Wickramasinghe & G. T. Bryan

Authors
  1. R. H. Wickramasinghe
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  2. G. T. Bryan
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Additional information

Acknowledgements. Supported by DHEW Grants No. AM-07616 from the National Institute of Arthritis and Metabolic Diseases and No.RR-73 from the General Clinical Research Centers Branch of the Division of Research Resources, National Institutes of Health, USPHS.

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Wickramasinghe, R.H., Bryan, G.T. Effect of progesterone on human corticosteroid 21-hydroxylation. Experientia 31, 1366–1367 (1975). https://doi.org/10.1007/BF01945831

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  • DOI: https://doi.org/10.1007/BF01945831

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