Summary
Histamine content in the rat hypothalamus was lower at 4°C and higher at 31°C compared to that at 21°C. Pretreatment with α-fluoromethylhistidine, a ‘suicide’ inhibitor of histidine decarboxylase, attenuated both the increased level of hypothalamic histamine and rat adaptive behavior at 31°C. Increase of histamine content in the hypothalamus appears to be an important factor contributing to rat adaptive behavior to high environmental temperature.
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Fujimoto, K., Sakata, T., Ookuma, K. et al. Hypothalamic histamine modulates adaptive behavior of rats at high environmental temperature. Experientia 46, 283–285 (1990). https://doi.org/10.1007/BF01951767
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DOI: https://doi.org/10.1007/BF01951767