Summary
The analgesic response to the hot-plate test was studied in 21-, 45-, 60-, 120- and 300-day-old rats maternally exposed to methadone (5 mg/kg). An elevation in nociceptive threshold, in the absence of further exposure to methadone, was observed in young and adult rats perinatally subjected to methadone.
Similar content being viewed by others
Literature
V.P. Dole and M.E. Nyswander, J. Am. med. Ass.193, 646 (1965).
G. Blinick, R.C. Wallach, E. Jerez and B. Ackerman, Am. J. Obstet. Gynec.125, 135 (1976).
G. Blinick, C.E. Inturrisi, E. Jerez and R.C. Wallach, Am. J. Obstet. Gynec.121, 617 (1975).
A. Lodge, M.M. Marcus and C.M. Ramer, Int. J. Addict.2, 235 (1975).
P.J. McLaughlin, I.S. Zagon and W.J. White, Biologia Neonat.34, 48 (1978).
A.L. Misra and S.J. Mule, Nature,238, 155 (1972).
M.A. Peters, J. Pharmac. exp. Ther.192, 513 (1975).
M.A. Peters, M. Turnbow and D.J. Buchenauer, J. Pharmac. exp. Ther.181, 273 (1972).
G. Blinick, E. Jerez and R.C. Wallach, J. Am. med. Ass.224, 447 (1973).
C.M. Ramer and A. Lodge, Int. J. Addict.2, 227 (1975).
R.Y. Ting, A. Keller and L.P. Finnegan, Proc. 2nd nat. Drug Abuse Conf., New Orleans 1975.
G. Wilson, Addict. Dis.2, 333 (1975).
I.S. Zagon and P.J. McLaughlin, Biologia Neonat.31, 271 (1977).
I.S. Zagon and P.J. McLaughlin, Exp. Neurol.56, 538 (1977).
I.S. Zagon and P.J. McLaughlin, Experientia33, 1486 (1977).
I.S. Zagon and P.J. McLaughlin, J Neurochem.31, 49 (1978).
I.S. Zagon and P.J. McLaughlin, Pharmac. Biochem. Behav.9, 665 (1978).
I.S. Zagon, P.J. McLaughlin and C.I. Thompson, Pharmac. Biochem. Behav.10, 743 (1979).
I.S. Zagon, P.J. McLaughlin and C.I. Thompson, Pharmac. Biochem. Behav.10, 889 (1979).
G. Woolfe and A.D. McDonald, J. Pharmac. exp. Ther.80, 300 (1944).
B.J. Winer, Statistical Principles in Experimental Design. McGraw-Hill, New York 1971.
Author information
Authors and Affiliations
Additional information
This research was supported by grant DA 01618.
Rights and permissions
About this article
Cite this article
Zagon, I.S., McLaughlin, P.J. Protracted analgesia in young and adult rats maternally exposed to methadone. Experientia 36, 329–330 (1980). https://doi.org/10.1007/BF01952306
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01952306