Abstract
We describe a patient with recurrent respiratory papillomatosis (RRP) associated with human papilloma virus (HPV), who developed a fatal squamous cell carcinoma of the lung. At the age of 1 year he presented with hoarseness, dyspnoea and inspiratory stridor but the diagnosis of RRP was made only 1 year later. At the age of 4 years he was tracheostomized because of upper airway obstruction. In spite of multiple surgical excisions and topic treatment with 5-fluoruacil the papillomata extended to the lung parenchyma. At the age of 16 years he developed a squamous-cell carcinoma of the lung and died 4 months later. Transformation to pulmonary carcinoma is a rare complication in non-irradiated patients with lung papillomatosis. We found only 11 similar cases in the literature.
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Abbreviations
- HPV:
-
human papilloma virus
- RRP:
-
recurrent respiratory papillomatosis
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Simma, B., Burger, R., Uehlinger, J. et al. Squamous-cell carcinoma arising in a non-irradiated child with recurrent respiratory papillomatosis. Eur J Pediatr 152, 776–778 (1993). https://doi.org/10.1007/BF01954001
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DOI: https://doi.org/10.1007/BF01954001