Abstract
The effects of intravenous injection of PAF-acether and of leukotrienes LTB4 and LTD4 on rabbit retina were determinedin vivo in the unanaesthetized animal. PAF-acether induced an intense ischemia accompanied by a marked plasma leakage. The extravasation remained both in the platelet-depleted rabbit where a sludge phenomenon appeared and in the reserpine-treated animal. Prostacyclin injected after PAF-acether restored only partially the normal retinal appearance.
The effect of LTC4 and LTD4 was markedly less intense than PAF-acether which is not too surprising in this species, given the previous results.
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Braquet, P., Vidal, R.F., Braquet, M. et al. Involvement of leukotrienes and PAF-acether in the increased microvascular permeability of the rabbit retina. Agents and Actions 15, 82–85 (1984). https://doi.org/10.1007/BF01966977
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DOI: https://doi.org/10.1007/BF01966977