Skip to main content
SpringerLink
Log in

The mode of action of aspirin-like drugs

  • Immunosuppression and Inflammation
  • Editorials
  • Published:
Agents and Actions Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. M.J.H. Smith,Prostaglandins and Aspirin: An Alternative View, Agents and Actions5, 315–317 (1975).

    PubMed  Google Scholar 

  2. M.J.H. Smith, This issue.

  3. J.R. Vane,Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs, Nature, New Biol.231, 232–235 (1971).

    Google Scholar 

  4. R.J. Flower,Drugs which Inhibit Prostaglandin Biosynthesis, Pharmacol. Rev.26, 33–67 (1974).

    PubMed  Google Scholar 

  5. S.H. Ferreira andJ.R. Vane,New Aspects of the Mode of Action of Non-Steroid Anti-Inflammatory Drugs, Ann. Rev. Pharmacol.14, 57–73 (1974).

    Article  Google Scholar 

  6. G.J. Roth, N. Stanford andP.W. Majerus,Acetylation of Prostaglandin Synthetase by Aspirin, Proc. Natl. Acad. Sci. USA72, 3073–3076 (1975).

    PubMed  Google Scholar 

  7. S. Moncada, R. Gryglewski, S. Bunting andJ.R. Vane,An Enzyme Isolated from Arteries Transforms Prostaglandin Endoperoxides to an Unstable Substance that Inhibits Platelet Aggregation, Nature, Lond.263, 663–665 (1976).

    Google Scholar 

  8. S. Moncada andJ.R. Vane,The Discovery of Prostacyclin (PGX); a Fresh Insight into Arachidonic Acid Metabolism, in:Biochemical Aspects of Prostaglandins and Thromboxanes (Eds. N. Kharasch and J. Fried; Academic Press, 1977), pp. 155–177.

  9. M. Hamberg, J. Svensson andB. Samuelsson,Thromboxanes: A New Group of Biologically Active Compounds Derived from Prostaglandin Endoperoxides, Proc. Natl. Acad. Sci. USA72, 2994–2998 (1975).

    PubMed  Google Scholar 

  10. F.A. Kuehl Jr., J.L. Hules, R.W. Egan, E.A. Ham, G.C. Beveridge andC.G. Van Arman,Role of Prostaglandin Endoperoxide PGG 2 in Inflammatory Processes, Nature, Lond.265, 170–173 (1977).

    Google Scholar 

  11. H.O.J. Collier andW.J.F. Sweatman,Antagonism by Fenamates of Prostaglandin F 2α and Slow Reacting Substance on Human Bronchial Muscle, Nature, Lond.219, 864–865 (1968).

    Google Scholar 

  12. A.G.A. Flores andG.W.G. Sharp,Exogenous Prostaglandins and Osmotic Water Flow in the Toad Bladder, Amer. J. Physiol.223, 1392–1397 (1972).

    PubMed  Google Scholar 

  13. R.J. Gryglewski, B. Panczenko, R. Korbut, L. Grodzinska andA. Ocetkiewicz,Corticosteroids Inhibit Prostaglandin Release from Perfused Mesenteric Blood Vessels of Rabbit and from Perfused Lungs of Sensitized Guinea Pig, Prostaglandins10, 343–355 (1975).

    Article  PubMed  Google Scholar 

  14. S.L. Hong andL. Levine,Inhibition of Arachidonic Acid Resease from Cells as the Biochemical Action of Anti-Inflammatory Corticosteroids, Proc. Natl. Acad. Sci. USA73, 1730–1734 (1976).

    PubMed  Google Scholar 

  15. F.P. Nijkamp, R.J. Flower, S. Moncada andJ.R. Vane,Partial Purification of Rabbit Aorta Contracting Substance-Releasing Factor and Inhibition of its Activity by Anti-Inflammatory Steroids, Nature, Lond.263, 479–482 (1976).

    Google Scholar 

  16. N.L. Baenziger, M.J. Dillender andP.W. Majerus,Cultured Human Skin Fibroblasts and Arterial Cells Produce a Labile Platelet-Inhibitory Prostaglandin, Biochem. Biophys. Res. Commun.78, 294–301 (1977).

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Wellcome Research Laboratories Langley Court, BR3 3BS, Beckenham, Kent, England

    J. R. Vane

Authors
  1. J. R. Vane
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Vane, J.R. The mode of action of aspirin-like drugs. Agents and Actions 8, 430–431 (1978). https://doi.org/10.1007/BF01968671

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01968671

Search

Navigation