Abstract
The first case ofClostridium difficile toxin-induced reactive arthritis in a patient with chronic Reiter's syndrome is described and compared with previous cases of reactive arthritis associated with this organism. This case demonstrates how distinct clinical manifestations may develop at different times in Reiter's syndrome, according to the infecting organism. Diagnostic terminology is discussed in this context.Clostridium difficile should now be considered a firmly established cause of reactive arthritis.
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Fairweather SD, George RH, Keighley MRB Arthritis in pseudomembranous colitis associated with an antibody toClostridium difficile toxin. Journal of the Royal Society of Medicine 1980, 73: 524–525.
Berglof FE Arthritis and intestinal infection. Acta Rheumatologica Scandinavica 1963, 9: 141–149.
Paronen I Reiter's disease: a study of 344 cases observed in Finland. Acta Rheumatologica Scandinavica 1948, Supplement 212: 1–114.
Ahronen P, Sievers K, Aho K Arthritis associated withYersinia enterocolitica infection. Acta Rheumatologica Scandinavica 1969, 15: 232–253.
Urman JD, Zurier RB, Rothfield NF Reiter's syndrome associated withCampylobacter foetus infection. Annals of Internal Medicine 1977, 86: 444–445.
Rollins RE, Moeller D Acute migratory polyarthritis associated with antibiotic-induced pseudomembranous colitis. American Journal of Gastroenterology 1976, 65: 353–355.
Hannonen P, Hakola M, Mottonen T, Oka M Reactive oligoarthritis associated withClostridium difficile colitis. Scandinavian Journal of Rheumatology 1989, 18: 57–60.
Brewerton DA HLA-B27 and the inheritance of susceptibility to rheumatic disease. Arthritis and Rheumatism 1976, 19: 656–668.
Stein HB, Abdullah A, Robinson HS Salmonella reactive arthritis in British Columbia. Arthritis and Rheumatism 1980, 23: 206–210.
Leung FY-K, Littlejohn GO, Bombardier C Reiter's syndrome afterCampylobacter jejuni enteritis. Arthritis and Rheumatism 1980, 23: 948–950.
Marsal L, Winblad S, Wollheim FA Yersinia enterocolitica arthritis in southern Sweden; a four-year follow-up study. British Medical Journal 1981, 283: 101–103.
Keat A Reiter's syndrome and reactive arthritis in perspective. New England Journal of Medicine 1983, 309: 1606–1614.
Aho K Yersinia arthritis and related diseases: clinical and immunogenetic implications. In: Dumonde DC (ed): Infection and immunology in the rheumatic diseases. Blackwell Scientific, Oxford, 1976, p. 341–344.
Rothschild BM, Masi AT, June PL Arthritis associated with ampicillin colitis. Archives of Internal Medicine 1977, 137: 1605–1607.
Hodgson HJ, Potter JF, Jewell DP Immune complexes in ulcerative colitis and Crohn's disease. Clinical and Experimental Immunology 1977, 29: 187–196.
Gemmel CG Comparative study of the nature and biological activities of bacterial endotoxins. Journal of Medical Microbiology 1984, 17: 217–235.
Chang Te-Wen: Antibiotic-associated injury to the gut. In: Berg JE (ed): Bockus gastroenterology. W.B. Saunders, 1985, p. 2583–2592.
Smith MD, Gibson RA, Brooks PR Abnormal bowel permeability in ankylosing spondylitis and rheumatoid arthritis. Journal of Rheumatology 1985, 12: 299–305.
Bolton RP, Wood GM, Losowsky MS Acute arthritis associated withClostridium difficile colitis. British Medical Journal 1981, 283: 1023–1024.
McCluskey J, Riley TV, Owen ET, Langlands DR Reactive arthritis associated withClostridium difficile. Australian and New Zealand Journal of Medicine 1982, 12: 535–537.
Lofgren RP, Tadlock LM, Soltis RD Acute oligoarthritis associated withClostridium difficile pseudomembranous colitis. Archives of Internal Medicine 1984, 144: 617–619.
Abbott WG, Cauchey DE Reactive arthritis due toClostridium difficile. New Zealand Medical Journal 1982, 95: 287.
Atkinson MH, McLeod BD Reactive arthritis associated withClostridium difficile enteritis. Journal of Rheumatology 1988, 15: 520–522.
Mermel LA, Osborn TG Clostridium difficile associated reactive arthritis in an HLA-B27 positive female: report and literature review. Journal of Rheumatology 1988, 16: 133–135.
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Cope, A., Anderson, J. & Wilkins, E. Clostridium difficile toxin-induced reactive arthritis in a patient with chronic Reiter's syndrome. Eur. J. Clin. Microbiol. Infect. Dis. 11, 40–43 (1992). https://doi.org/10.1007/BF01971269
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DOI: https://doi.org/10.1007/BF01971269