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Effect of praseodymium on drug metabolism in rat liver smooth and rough endoplasmic reticulum

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Summary

A small i.v. dose (3 mg/kg) of a light lanthanon, praseodymium, impairs the drug metabolizing capacity of both the smooth and rough fractions of rat liver endoplasmic reticulum. This decrease in the activity of drug metabolizing enzymes and in the amount of cytochromes P-450 and b5 is more pronounced in the rough endoplasmic reticulum fraction.

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Authors and Affiliations

  1. Department of Pharmacology, Free University of Berlin, D-1000, Berlin, West

    P. Arvela, B. v. Lehmann, O. Grajewski & E. Oberdisse

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  1. P. Arvela
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  2. B. v. Lehmann
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  3. O. Grajewski
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  4. E. Oberdisse
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Arvela, P., v. Lehmann, B., Grajewski, O. et al. Effect of praseodymium on drug metabolism in rat liver smooth and rough endoplasmic reticulum. Experientia 36, 860–861 (1980). https://doi.org/10.1007/BF01978615

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  • DOI: https://doi.org/10.1007/BF01978615

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