Abstract
The effects of the T-cell-directed immunosuppressant cyclosporin A (CsA) on the developmnnt of antigen-induced arthritis (AIA) in rats as well as on cytokine levels in synovial fluid and serum were determined. The treatment with CsA effectively inhibited the chronic phase of arthritis as demonstrated by decreased joint swelling and reduced histological arthritic score. In animals with AIA the level of IL-6 in the synovial fluid and serum is increased, showing good correlation with the severity of the disease. The CsA treatment reduced IL-6 levels to normal. IL-1, IL-2 and TNF-α do not seem to be directly involved in the pathogenic mechanisms of chronic arthritis.
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References
P. Herve, E. Racadot, D. Wendling, L. Rumbach, P. Tiberghien, J. Y. Cahn, M. Flesch and J. Wijdenes,Use of monoclonal antibodies in vivo as a therapeutic strategy for alloimmune or autoimmune reactivity: the Besancon experience. Immunol. Rev.129, 31–55 (1992).
M. J. Crossley, T. Holland, M. Spowage and I. M. Hunneyball,Monoarticular antigen-induced arthritis in rabbits and mice. Modern Methods Pharmacol.,5, 415–439 (1989).
D. Brackertz, G. F. Mitchell, M. A. Vadas, I. R. Mackay and J. F. A. P. Miller,Studies on antigen-induced arthritis in mice II. Immunologic correlates of arthritis susceptibility in mice. J. Immunol.118, 1639–1644 (1977).
R. Bräuer, K. Thoss, S. Henzgen and G. Waldmann,Significance of cell-mediated and humoral immunity in the acute and chronic phase of antigen-induced arthritis in rabbits. Exp. Pathol.34, 197–208 (1988).
T. Krakauer and H. Krakauer,A method for the quantitative analysis and stadnrdization of interleukin-1 bioactivity. J. Leukocyte Biol.50, 123–130 (1991).
P. Miossec, M. Elhamiani, B. Chichehian, A. D. d'Angeac, J. Sany and M. Hirn,Interleukin-2 (IL-2) inhibitor in rheumtoid synovial fluid: Correlation with prognosis and soluble IL-2 receptor levels. J. Clin. Immunol.10, 115–120 (1990).
W. Feist, A. J. Ulmer, M.-H., Wang, J. Musehold, C. Schlüter, J. Gerdes, H. Herzbeck, H. Brade, S. Kusumoto, T. Diamantstein, E. T. Rietschel and H.-D. Flad,Modulation of lipopolysaccharide-induced production of tumor necrosis factor, interleukin 1, and interleukin 6 by synthetic precursor Ia of lipid A. FEMS Microbiol. Immunol.89, 73–90 (1992).
B. Henderson, F. M. Rowe, C. R. Bird and A. J. H. Gearing,Production of interleukin-1 in the joint during the development of antigen-induced arthritis. Clin. Exp. Immunol.74, 371–376 (1988).
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Bräuer, R., Kette, H., Henzgen, S. et al. Influence of cyclosporin A on cytokine levels in synovial fluid and serum of rats with antigen-induced arthritis. Agents and Actions 41, 96–98 (1994). https://doi.org/10.1007/BF01986404
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DOI: https://doi.org/10.1007/BF01986404