Summary
Both acute and chronic administration of morphine resulted in an increase in the percent cardiac output received by brain. However, various brain regions were affected differently by the drug treatments. The greatest increases in percent cardiac output received after chronic administration of morphine occurred in pons and cerebellum, while the greatest increases after acute administration occurred in cortex and midbrain. The changes found are in contrast with earlier studies which suggest that morphine has no effect on cerebral blood flow.
Literatur
Laubie, M., and Schmitt, H., Eur. J. Pharmac.71, (1981) 401; Fennessy, M.R., and Rattray, J.F., Eur. J. Pharmac.14 (1971) 1; Moore, R.H., and Dowling, D.A., Reg. Peptide1 (1980) 77; LeMaire, I., Tseng, R., and LeMaire, S., Proc. natn. Acad. Sci. USA75 (1978) 6240.
Yukimura, T., Stock, G., Stumpt, H., Unger, T., and Ganten, D., Hypertension3 (1981) 528; McQueen, D.S., and Ribeiro, J.A., Br. J. Pharmac.71 (1980) 297.
Holaday, J.W., and Faden, A.I., Brain Res.189, (1980) 295.
Faden, A.I., and Holaday, J.W., J. Pharmac. exp. Ther.212 (1980) 441.
Olesen, J., Brain94 (1971) 635; Kato, M., Ueno, H., and Black, P., Exp. Neurol.42 (1974) 65.
Kontos, H.A., Rasper, A.J., and Patternson, J.L. Stroke8 (1977) 358; Wahl, M., and Kuschinsky, W., Pflügers Arch.362 (1976) 55.
Kennedy, C., Des Rosiers, M.H., Jehle, J.W., Reivich, M., Sharpe, F., and Sokoloff, L., Science187 (1975) 850; Sokoloff, L., J. Neurochem.28 (1977) 897.
Jaffe, J.H., and Martin, W.R., in: The Pharmacological Basis of Therapeutics, 5th edn, chap. 15. Eds L.S. Goodman and A. Gilman. Macmillan Publishing Co., New York 1975.
Each set of microspheres (15±1 μm) was labelled with one of three isotopes:46Sc,85Sr or141Ce. Distribution of cardiac output was calculated according to the methods of, Ferguson, J.L., Spitzer, J.J., and Miller, H.I., J. surg. Res.25, (1978) 236.
McGinity, J., and Mehta, C., Pharmac. Biochem. Behav.9 (1978) 705.
Two-way ANOVA between tissue and time indicated a significant difference between pre- and post-treatment times in both acute and chronic treatment. Individual differences between time in each tissue were tested using paired t-test. The difference between the total brain percent change in chronic and acute treatments was tested for significance with Student's t-test after arcsin transformation of the data.
Kupferberg, H., Bukhalter, A., and Way, E., J. Pharmac. exp. Ther.145 (1964) 247.
Although 200 mg/kg morphine is higher than doses administered to many species, in pilot studies with guinea pigs, up to 400 mg/kg was administered before any mortality was observed. No seizures were observed in guinea pigs which received 200 mg/kg morphine i.v.
Mean left ventricular blood pressures:
Evans, A.G.J., Nasmyth, P.A., and Stewart, H.C., Br. J. Pharmac.7 (1952) 542; Fennessy, M.R., and Rattray, J.F., Eur. J. Pharmac.14 (1971) 1.
Vargish, T., Reynolds, D.G., Gurll, N.J., Lechner, R.B., Holaday, J.W., and Faden, A.I., Circ. Shock7 (1980) 31; Reynolds, D.G., Gurll, N.J. Vargish, T., Lechner, R.B., Faden, A.I., and Holaday, J.W., Circ. Shock7 (1980) 39.
Wolozin, B.L., Nishimura, S., and Pasternak, G.W., J. Neurosci.2, (1982) 708.
This work was supported by Chicago Heart Association grant No. C82-13 and BRSG 82508.
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Law, W.R., Ritzmann, R.F., Lee, J.M. et al. The effects of acute and chronic morphine on regional distribution of cardiac output in brain. Experientia 41, 78–80 (1985). https://doi.org/10.1007/BF02005885
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DOI: https://doi.org/10.1007/BF02005885