Abstract
Meriones unguiculatus (jirds or ‘gerbils’) were rendered hypo- or hyperthyroid by the addition of carbimazole or liothyronine to their diet, and in each of these states were found to be highly susceptible to the nephrotoxic effects of calcium gluconate. Histological studies showed that the pattern of induced nephrocalcinosis was the same in the hypo-, hyper- and eu-thyroid animals and was in the form of calcium deposits both within the cells of the proximal and distal convoluted tubules and in the basement membranes around such tubules.
In view of these findings analysis of thyroid function should perhaps be incorporated into the list of diagnostic procedures used in the investigation of patients with nephrocalcinosis and nephrolithiasis.
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References
Baker, R., Reaven, G., Sawyer, J.: Ground substance and calcification-influence of dye binding on nephrocalcinosis. J. Urol. (Baltimore)71, 511–522 (1954).
Clark, F., Brown, H. J.: Free thyroxine index. Brit. med. J. II, 543 (1970a)
Clark, F., Brown, H. J.: Free thyroxine index. Brit. med. J. II, 672 (1970b)
Clark, F., Brown, H. J.: Evaluation of Thyopac-3 test in thein vitro assessment of thyroid function. Brit. med. J.I, 713–715 (1970c)
Fourman, J.: Two distinct forms of experimental nephrocalcinosis in the rat. Brit. J. exp. Path.40, 464–473 (1959).
Grimes, W. A.: Phase contrast study of mechanisms of renal calcification. J. Urol. (Baltimore)78, 553–574 (1957)
Kepner, B. L., Hercules, D. M.: Fluorimetric determination of calcium in blood serum. Analyt. Chem.35, 1238–1240 (1963).
Kóssa, J. von: Über die im Organismus künstlich erzeugbaren Verkalkungen. Beitr. path. Anat.29, 163–202 (1901)
Lawson, A., Rimington, C., Searle, C. E.: Antithyroid activity of 2-carbethoxythio-1-methylglyoxaline. Lancet II, 619–621 (1951).
Mathieu, H., Habib, R., Cuisinier, P., Muller, P., Royer, P.: Néphrocalcinose du rat éthyroidé à la naissance par l'iode 131. Rev. Franç. Ét. clin. Biol.6, 657–669 (1961)
McGee-Russell, S. M.: A new reagent for the histochemical and chemical detection of calcium. Nature (Lond.)175, 301–302 (1955).
McGee-Russell, S. M.: Histochemical methods for calcium. J. Histochem. Cytochem.6, 22–42 (1958)
Newman, R. J.: The effects of thyroid hormone on vitamin D-induced nephrocalcinosis. J. Path.111, 13–21 (1973)
Pearse, A. G. E.: The Periodic Acid-Schiff reaction. Broadsheet No. 26, (new series). The Association of Clinical Pathologists (1959)
Radiochemical Centre, Amersham: Technical Bulletin 69/7 Thyopac-3. A new kit for T3 uptake testing (1969)
Steedman, H. F.: Alcian Blue 8GS: A new stain for mucin. Quart. J. micr. Sci.91, 477–479 (1950)
Trinder, P.: Colorimetric microdetermination of calcium in serum. Analyst85, 889–894 (1960)
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Newman, R.J. The effect of thyroid hormone on calcium-induced nephrocalcinosis in the jird (Meriones unguiculatus). Calc. Tis Res. 16, 157–162 (1974). https://doi.org/10.1007/BF02008222
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DOI: https://doi.org/10.1007/BF02008222