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Comments on the significance of the quasi-valence number for chemical carcinogenesis

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Summary

A quasi-valence number of less than 3.20 was reported to be significant in correlating carcinogenicity. This criterion has no meaningful relationship since such a large proportion of organic compounds fall in this group, that it provides no selectivity.

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References

  1. V. Veljkovic and D.I. Lalovic, Experientia33, 1228 (1977).

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  2. IARC Monographs, Evaluation of Carcinogenic Risk, Vol. 1–8, Lyon, France, 1972–1975.

  3. C.E. Searle, ed., Chemical Carcinogens. American Chemical Society, Washington, DC, ACS Monograph 173, 1976.

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Authors and Affiliations

  1. Department of Chemistry and Department of Basic Health Sciences, North Texas State University, 76203, Denton, Texas, USA

    R. E. Lyle & Gloria G. Lyle

  2. Texas College of Osteopathic Medicine, 76203, Denton, Texas, USA

    R. E. Lyle & Gloria G. Lyle

Authors
  1. R. E. Lyle
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  2. Gloria G. Lyle
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Additional information

Acknowledgment. The authors express appreciation to the American Cancer Society (CH-57), the National Institute of Environmental Health Sciences (1-RO1-ES01975-01 PTHB) and the Robert A. Welch Foundation (B-702) for financial assistance of projects related to this paper.

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Lyle, R.E., Lyle, G.G. Comments on the significance of the quasi-valence number for chemical carcinogenesis. Experientia 34, 1653–1654 (1978). https://doi.org/10.1007/BF02034733

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  • DOI: https://doi.org/10.1007/BF02034733

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