Abstract
Few studies have attempted to correlate neuroimaging with outcome in patients with glioblastoma. Our aim was to evaluate the relationship between neuroradiological findings and survival in these patients. We studied 18 consecutive patients with glioblastoma who had undergone surgery and radiotherapy. We assessed the following features, using preoperative CT and/or MRI: tumour size, extent of necrotic area within the mass, extent of perifocal oedema and contrast enhancement. The mean survival was 14.2 ± 5 months (range 6–22). The extent of radiological evidence of necrosis within the mass correlated significantly with survival time, whereas tumour size, perifocal oedema and contrast enhancement did not.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
EORTC Brain Tumor Group (1991) Cisplatin does not enhance the effect of radiation therapy in malignant gliomas. Eur J Cancer 27: 568–571
Devaux BC, O'Fallon JR, Kelly PJ (1993) Resection, biopsy and survival in malignant glial neoplasm. A retrospective study of clinical parameters, therapy and outcome. J Neurosurg 78: 767–775
Fine HA, Dear KB, Loeffer JS, Black PM, Canellos GP (1993) Meta-analysis of radiation therapy with and without adjuvant chemotherapy for malignant gliomas in adults. Cancer 71: 2585–2597
Taillandier T, Bracard S, Anxionnat R, Debouverie M, Baylac F, Duprez A, Weber M (1994) Neuroradiological prognostic factors of adult supratentorial astrocytoma. Neuroradiology 36 [Suppl 1]: S50
Tervonen O, Forbes G, Scheithauer BW, Dietz MJ (1992) Diffuse “fibrillary” astrocytomas: correlation of MRI features with histopathologic parameters and tumor grade. Neuroradiology 34: 173–178
Watanabe M, Tanaka R, Takeda N (1992) Magnetic resonance imaging and histopathology of cerebral gliomas. Neuroradiology 34: 463–469
Pierallini A, Bonamini M, Di Stefano D, Fantozzi LM, Cantore G, Bozzao L (1994) Neuroradiologia degli astrocitomi. Riv Neuroradiol 7 [Suppl 1]: 15–21
Kleihues P, Burger PC, Scheithauer BW (1993) Histological typing of tumors of the central nervous system. WHO international histological classification of tumor series, 2nd edn. Springer, Berlin Heidelberg New York
Nelson JS, Tsukada Y, Schoenfeld D, Fulling K, Lamarche J, Peress N (1983) Necrosis as a prognostic criterion in malignant supratentorial astrocytic gliomas. Cancer 52: 550–554
Hoshino T, Prados M, Wilson CB, Gi Cho K, Lee KS, Davis RL (1989) Prognostic implications of the bromodeoxyuridine labeling index of human gliomas. J Neurosurg 71: 335–341
Burger PC, Vogel FC, Green SB, Strike TA (1985) Glioblastoma multiforme and anaplastic astrocytoma: pathologic criteria and prognostic implications. Cancer 56: 1106–1111
Kim TS, Halliday AL, Hedley-Whyte ET, Convery K (1991) Correlates of survival and the Daumas-Duport grading system for astrocytomas. J Neurosurg 74: 27–37
Simpson JR, Horton J, Scott C, Curran WJ, Rubin P, Fischbach J, Isaacson S, Rotman M, Asbell SO, Nelson JS, et al (1993) Influence of location and extent of surgical resection on survival of patients with glioblastoma multiforme: results of three consecutive Radiation Therapy Oncology Group (RTOG) clinical trials. Int J Radiat Oncol Biol Phys 26: 239–244
Chamberlain MC, Murovic JA, Levin VA (1988) Absence of contrast enhancement on CT brain scans of patients with supratentorial malignant glioma. Neurology 38: 1371–1374
Kallio M, Sankila R, Jaaskelainen J, Karjalainen S, Hakulinen T (1991) A population-based study on the incidence and survival rates of 3857 glioma patients diagnosed from 1953 to 1984. Cancer 68: 1394–1400
Bamberg M, Hess CF (1992) Radiation therapy of malignant gliomas. Onkologie 15: 178–189
Curran WJ Jr, Scott CB, Nelson JS, Weinstein AS, Philipps TL, Murray K, Fischbach AJ, Yakar D, Schwade JG, Powlis WD, Nelson DF (1992) A randomized accelerated hyperfractionated radiation therapy and bis-chlorethyl nitrosourea for malignant glioma: a preliminary report of Radiation Therapy Oncology Group 83-02. Cancer 70: 2909–2917
Watne K, Nome O, Hager B, Hirschberg H (1992) Pre-radiation chemotherapy in patients with poor prognostic factors. J Neurooncol 13: 261–264
Kreth FW, Warnke PC, Scheremet R, Ostertag CB (1993) Surgical resection and radiation therapy versus biopsy and radiation therapy in the treatment of glioblastoma multiforme. J Neurosurg 78:762–766
Peschel RE, Wilson L, Haffty B, Papadopoulos D, Rosenzweig K, Feltes M (1993) The effect of advanced age on the efficacy of radiation therapy for early breast cancer, local prostate cancer and grade III–IV gliomas. Int J Radiat Oncol Biol Phys 26: 539–544
Ciric I, Ammirati M, Vick N, Mikhael M (1987) Supratentorial gliomas: surgical considerations and immediate postoperative results. Gross total resection versus partial resection. Neurosurgery 21: 21–26
Hollerhage HG, Zumkeller M, Becker M, Dietz H (1991) Influence of type and extent of surgery on early results and survival time in glioblastoma multiforme. Acta Neurochir (Wien) 113: 31–37
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Pierallini, A., Bonamini, M., Osti, M.F. et al. Supratentorial glioblastoma: Neuroradiological findings and survival after surgery and radiotherapy. Neuroradiology 38 (Suppl 1), S26–S30 (1996). https://doi.org/10.1007/BF02278114
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02278114