Abstract
A condition similar to massive periretinal proliferation in man can be produced in rabbits by injecting homologous fibroblasts into the vitreous. We have studied the effect of daunomycin, a cytotoxic drug, in this model to determine a dose which would not be toxic to the retina but would be effective in preventing proliferation of the injected fibroblasts and eventual retinal detachment. The results of this study demonstrate that daunomycin at a dose of 9 nmol per eye reduces the incidence of retinal detachment by over 50%. Doses higher than 30 nmol per eye are toxic to the retina.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Algvere P, Kock E (1976) Experimental fibroplasia in the rabbit vitreous: retinal detachment induced by autologous fibroblasts. Graefe's Arch Clin Exp Ophthalmol 199: 215–222
Blumenkranz MS, Ophir A, Clafin AJ, Hajek A (1982) Fluorouracil for the treatment of massive periretinal proliferation. Am J Ophthalmol 94: 458–467
Cleary PE, Ryan SJ (1981) Mechanisms in traction retinal detachment. Dev Ophthalmol 2: 328–333
Fastenberg DM, Diddie KR, Dorey K, Ryan SJ (1982) The role of cellular proliferation in an experimental model of massive periretinal proliferation. Am J Ophthalmol 93: 565–572
Freeman HM (1973) Recent advances in vitreous surgery. Invest Ophthalmol Vis Sci 12: 549–551
Machemer R, Sugita G, Tano Y (1979) Treatment of intraocular proliferation with intravitreal steroids. Trans Am Ophthalmol Soc 77: 171–180
Meyers SM, Rodrigues MM (1981) Effect of selected intravitreal drugs after severe penetrating injury in rabbits. Curr Eye Res 1: 471–477
Stern WH, Fisher SK, Anderson DH, Lewis GP, Guerin CJ, Erickson PA, O'Donnell JJ (1982) Intraocular 5-fluorouracil therapy of experimental massive periretinal proliferation. Invest Ophthalmol Vis Sci 22 (ARVO suppl) p 230
Sugita G, Tano Y, Machemer R, Abrams G, Claflin A, Fiorentino G (1980) Intravitreal autotransplantation of fibroblasts. Am J Ophthalmol 89: 121–130
Tano Y, Sugita G, Abrams G, Machemer R (1980a) Inhibition of intraocular proliferation with intravitreal corticosteroids. Am J Ophthalmol 89: 131–136
Tano Y, Chandler D, Machemer R (1980b) Treatment of intraocular proliferation with intravitreal injection of triamcinolone acetonide. Am J Ophthalmol 90: 810–876
Tano Y, Chandler DB, McCuen BW, Machemer R (1981) Glucocorticosteroid inhibition of intraocular proliferation after injury. Am J Ophthalmol 91: 184–189
Topping DM, Abrams GW, Machemer R (1979) Experimental double-perforating injury of the posterior segment in rabbit eyes. The natural history of intraocular proliferation. Arch Ophthalmol 97: 735–742
Author information
Authors and Affiliations
Additional information
This work was supported in part by an NIH grant EY03040 and an award from Research to Prevent Blindness, Inc., New York, New York
Rights and permissions
About this article
Cite this article
Wiedemann, P., Kirmani, M., Santana, M. et al. Control of experimental massive periretinal proliferation by daunomycin: dose-response relation. Graefe's Arch Clin Exp Ophthalmol 220, 233–235 (1983). https://doi.org/10.1007/BF02308080
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02308080