Abstract
The authors report a case of multiple system atrophy (MSA) with an onset as a peripheral nerve involvement. Their patient, a 55-year-old man, had a 3-year history of distal weakness and atrophy in upper limbs with dysesthesia in the feet. Other identifiable causes of peripheral neuropathy were ruled out. The authors postulate that peripheral nervous system impairment can anticipate the typical appearance of MSA, and they suggest that, in peripheral neuropathies with autonomic system dysfunction, after excluding main causes of autonomic neuropathy, MSA may need to be suspected.
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References
Mathias CJ, Bannister R. Autonomic failure. In:A textbook of clinical disorders of the autonomic nervous system. 4th ed. Oxford: Oxford University Press; 1999. pp. 308–316.
Schultz JB, Klockgether T, Petersen D,et al. Multiple system atrophy: natural history, MRI morphology and dopamine receptor imaging with 123IBZM-SPECT.J Neurol Neurosurg Psychiatry 1994; 57(9):1047–1056.
Wenning GK, Ben-Shlomo Y, Magales M,et al. Clinical features and natural history of multiple system atrophy: an analysis of 100 cases.Brain 1994; 117:835–845.
Gilman S, Low P, Quinn N,et al. Consensus statement on the diagnosis of multiple system atrophy.Clin Auton Res 1998; 8:359–362.
Vita G, Princi P, Calabrò R,et al. Cardiovascular reflex tests: assessment of age-adjusted normal range.J Neurol Sci 1986; 75:263–274.
Guindi GM, Bannister R, Gibson WBR,et al. Laryngeal electromyography in multiple system atrophy with autonomic failure.J Neurol Neurosurg Psychiatry 1981; 44:49–53.
Williams A, Hanson D, Calne DB. Vocal cord paralysis in the Shy-Drager syndrome.J Neurol Neurosurg Psychiatry 1979; 42: 151–153.
Pramsteller PP, Wenning GK, Smith SJM,et al. Nerve conduction studies, skeletal muscle EMG, and sphincter EMG in multiple system atrophy.J Neurol Neurosurg Psychiatry 1995; 58:618–621.
Galassi G, Nemni R, Baraldi A,et al. Peripheral neuropathy in multiple system atrophy with autonomic failure.Neurology 1982; 32:1116–1121.
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Rodolico, C., Toscano, A., De Luca, G. et al. Peripheral neuropathy as the presenting feature of multiple system atrophy. Clinical Autonomic Research 11, 119–121 (2001). https://doi.org/10.1007/BF02322056
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DOI: https://doi.org/10.1007/BF02322056