Abstract
Food restriction (FR) was tested for its ability to protect against age-related membrane deterioration of kidney. Mitochondria and microsomes were isolated from male Fischer 344 rats that were either fed ad libitum (AL) or food restricted (60% of ad libitum). The result show the yields of isolated membranes decreased considerably with age in AL fed rats, but much less so in FR rats. Additional information on membrane protection by food restriction came from the analysis of membrane fatty acid composition: the amount of total saturated membrane fatty acid and highly oxidizable arachidonic acid increased in AL rats, and this was effectively modulated by food restriction.
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Yu, B.P., Masoro, E.J., Murata, I., Bertrand, H.A., and Lynd, F.T.: Lifespan study of SPF Fischer 344 male rats fed ad libitum or restricted diets: Longevity, growth, lean body mass and disease. J. Gerontol., 37: 130–141, 1982.
Masoro, E.J.: Nutrition as a modulator of the aging process. The Physiologist, 27: 98–101, 1983.
Weindruch, R.: Dietary restriction and the aging process, in Free Radicals in Molecular Biology, Aging and Disease, edited by Armstrong, D., Sohal, R.S., Cutler, R.G., and Slater, T.F., New York, Raven Press, 1984, pp. 181–202.
Yu, B.P., Masoro, E.J., and McMahan, C.A.: Nutritional influences on aging of Fischer 344 rats: 1. Physical, metabolic and longevity characteristics. J. Gerontol., 40: 657–670, 1985.
Yu, B.P.: Update on food restriction and aging, in Review of Biological Research in Aging, Vol. III, edited by Rothstein, M., New York, Alan R. Liss, Inc., 1987, pp. 495–505.
Maeda, H., Gleiser, C.A., Masoro, E.J., Murata, I., McMahan, C.A., and Yu, B.P.: Nutritional influences on aging of Fischer 344 rats. II. Pathology. J. Gerontol., 40: 671–688, 1985.
Hayashida, M., Yu, B.P., Masoro, E.J., Iwasaki, K., and Ikeda, T.: An electron microscopic examination of age-related changes in the rat kidney: The influence of diet. Exp. Gerontol., 21: 535–553, 1988.
Everitt, A.V., Porter, B.D., and Wyndham, J.R.: Effects of caloric intake and dietary composition on the development of proteinuria, age-associated renal disease and longevity in the male rat. Gerontology, 28: 168–175, 1982.
Johnson, K.J., Rehan, A., and Ward, P.: The role of oxygen radicals in kidney disease, in Oxygen Radicals and Tissue Injury, edited by Halliwell, B., Bethesda, Fed. Am. Soc. for Exp. Biol., 1988, pp. 115–122.
Harman, D.: Free radical theory of aging: Role of free radicals in origination and evolution of life, aging, and disease processes, in Free Radicals, Aging, and Degenerative Diseases, edited by Johnson, J.E., Jr., Walford, R., Harman, D., and Miguel, I., New York, Alan R. Liss, Inc., 1986, pp. 3–49.
Laganiere, S., and Yu, B.P.: Anti-lipoperoxidation action of food restriction. Biochem. Biophys. Res. Commun., 145: 1185–1191, 1987.
Del Maestro, R.F.: An approach to free radicals in medicine and biology. Acta. Physiol. Scand. Suppl., 492: 43–57, 1980.
Mead, J.F.: Free radical mechanisms in lipid peroxidation and prostaglandins, in Free Radicals in Molecular Biology, Aging, and Disease, edited by Armstrong, D., Sohal, R.S., Cutler, R.G., and Slater, T.F., New York, Raven Press, 1984, pp. 53–66.
Tate, E.L., and Herbener, B.H.: A morphometric study of the density of mitochondrial cristae in heart and liver of aging mice. J. Gerontol., 31: 129–134, 1976.
Tauchi, H., and Sato, T.: Changes in hepatic cell mitochondria during parabiosis between old and young rats. Mech. Ageing Dev., 12: 7–14, 1980.
Grinna, L.S.: Changes in cell membranes during aging. Gerontology, 23: 452–464, 1977.
Fleming, J.E., Miguel, J., Cottrell, S.F., Yengoyan, L.S., and Economos, A.C.: Is cell aging caused by respiration-dependent injury to the mitochondrial genome? Gerontology, 28: 44–53, 1982.
Harman, D.: Free radical theory of aging: Consequences of mitochondrial aging. AGE: 86–94, 1983.
Vladimirov, A.Y., Olenev, V.I., Suslova, T.B., and Cheremisina, Z.P.: Lipid peroxidation in mitochondrial membrane, in Advances in Lipid Research, Vol. 17, edited by Paoletti, R., and Kritchevsky, D., New York, Academic Press, 1980, pp. 173–249.
Masoro, E.J., and Yu, B.P:.: Diet and nephropathy. Lab Invest., 60: 165–167, 1989.
Lowry, O.H., Roseborough, N.J., Farr, L.A., and Randall, R.J.: Protein measurement with the Folin phenol reagent. J. Biol. Chem., 193: 265–275, 1951.
Folch, J., Lees, M., and Sloane Stanley, G.H.: A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem., 226: 497–509, 1957.
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Choi, JH., Yu, B.P. The effect of food restriction on kidney membrane structures of aging rats. AGE 12, 133–136 (1989). https://doi.org/10.1007/BF02432350
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DOI: https://doi.org/10.1007/BF02432350