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Synthesis of 5α-dihydrotestosterone in human bone tumors of various histological structure

  • Oncology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

In human primary bone tumors of various histological origins, metabolism of testosterone led to the formation of 5α-reduced metabolites (mainly 5α-androstane-3α, 17β-diol, and 5α-androstane-3β-17β-diol), but not 5α-dihydrotestosterone. Transformation of 5α-dihydrotestosterone to other metabolites in human primary osteosarcomas is assumed to be associated with its inactivation or involvement of metabolites of this androgen in unknown regulatory mechanisms in bone tumors. Therefore,in vitro evaluation of 5α-reductase activity in human primary osteosarcomas and other tumors by 5α-dihydrotestosterone formation could yield erroneous results.

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Authors and Affiliations

  1. N. N. Blokhin Russian Oncology Research Center, Russian Academy of Medical Sciences, Moscow

    V. G. Degtyar', T. V. Babkina, N. E. Kushlinskii, Yu. N. Solov'ev & N. N. Trapeznikov

Authors
  1. V. G. Degtyar'
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  2. T. V. Babkina
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  3. N. E. Kushlinskii
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  4. Yu. N. Solov'ev
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  5. N. N. Trapeznikov
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 128, No. 7, pp. 73–75, July, 1999

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Degtyar', V.G., Babkina, T.V., Kushlinskii, N.E. et al. Synthesis of 5α-dihydrotestosterone in human bone tumors of various histological structure. Bull Exp Biol Med 128, 722–724 (1999). https://doi.org/10.1007/BF02433326

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  • DOI: https://doi.org/10.1007/BF02433326

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