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Protocol of radiotherapy for glioblastoma according to the expression of HIF-1

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Abstract

Hypoxia is a common feature of many malignant neoplasms and has been identified as a major reason for the radioresistance of malignant tumor tissue. On the other hand, the transcription factor hypoxia-inducible factor-1 (HIF-1) has attracted attention because it is rapidly expressed when tissue oxygen tension is reduced, thus playing the role of a hypoxic sensor. We investigated whether the level of HIF-1 expression in glioblastoma (GBM) could be an indicator in a protocol for postoperative radiotherapy. We immunohistologically evaluated the level of HIF-1 expression in 60 pathologically diagnosed GBMs. HIF-1 expression was positive in all tumors. The progression-free survival of the group receiving only conventional radiotherapy after surgery differed significantly according to the level of HIF-1 expression. The results of this study suggest that the HIF-1 expression level can be an indicator of tumor radioresistance, and that prior knowledge of the HIF-1 expression level allows the formulation of a protocol for post-operative radiotherapy.

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Authors and Affiliations

  1. Department of Neurosurgery, Nagasaki University Hospital, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan

    Nobuyuki Irie, Takayuki Matsuo & Izumi Nagata

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  1. Nobuyuki Irie
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  2. Takayuki Matsuo
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  3. Izumi Nagata
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Correspondence to Nobuyuki Irie.

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Irie, N., Matsuo, T. & Nagata, I. Protocol of radiotherapy for glioblastoma according to the expression of HIF-1. Brain Tumor Pathol 21, 1–6 (2004). https://doi.org/10.1007/BF02482169

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  • DOI: https://doi.org/10.1007/BF02482169

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