Skip to main content
SpringerLink
Log in

Quinones and quinols as inhibitors of lipid peroxidation

  • Published:
Lipids

Abstract

The influence of biological quinonoid compounds upon oxidative polymerization of lipids has been compared with that of simple quinones and antioxidants. A new procedure for the accelerated production and measurement of oxidative polymerization was used for this comparison. The biological quinones were found to be relatively ineffective as retarders of oxidative polymerization. Heme-catalyzed lipid peroxidation, as measured by oxygen uptake, was inhibited by ubiquinone and ubiquinol, both having about one fourth of the antioxidant capacity ofa-tocopherol. The peroxidation of mitochondrial lipid in vitro was inhibited by the presence of exogenous ubiquinone indicating that this compound may contribute towards the protection of the organelle in vivo.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Morton, R. A., Endeavour24, 81–86 (1965).

    Article  PubMed  CAS  Google Scholar 

  2. Folkers, K., J. L. Smith and H. W. Moore, Federation Proc.24, 79–84 (1965).

    CAS  Google Scholar 

  3. Ayrey, G., Chem. Rev.63, 645–667 (1963).

    Article  Google Scholar 

  4. Martius, C., and H. Eilingsfeld, Ann.607, 159–168 (1957).

    CAS  Google Scholar 

  5. Schneider, W. C., J. Biol. Chem.176, 259–266 (1948).

    CAS  Google Scholar 

  6. Lea, C. H., and A. Kwietny, Chem. Ind. (London),24, 1245–1246 (1962).

    Google Scholar 

  7. Kaufmann, H. P., and H. Garloff, Fette Seifen Anstrichmittel63, 334–344 (1961).

    Article  CAS  Google Scholar 

  8. Tappel, A. L., and H. Zalkin, Arch. Biochem. Biophys.80, 326–332 (1959).

    Article  CAS  Google Scholar 

  9. Crane, F. L., Biochim. Biophys. Acta31, 476–489 (1959).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Food Science and Technology, University of California, Davis, California

    A. Mellors & A. L. Tappel

Authors
  1. A. Mellors
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. L. Tappel
    View author publications

    You can also search for this author in PubMed Google Scholar

About this article

Cite this article

Mellors, A., Tappel, A.L. Quinones and quinols as inhibitors of lipid peroxidation. Lipids 1, 282–284 (1966). https://doi.org/10.1007/BF02531617

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02531617

Keywords

Search

Navigation