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Bone mineral density measured by dual-energy X-ray absorptiometry in healthy finnish women

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Summary

A cross-sectional study of 351 healthy Finnish women aged 20–76 years was done to establish reference values of bone mineral density (BMD) using dual-energy X-ray absorptiometry (DEXA). The effects of age and of several physical and lifestyle factors on BMD of the lumbar spine and proximal femur (femoral neck, trochanter, and Ward's triangle area) were investigated. Altogether 58 women were excluded from the final analysis due to significant spinal osteoarthritis or other diseases or drugs known to influence calcium or bone metabolism. The precision of the method was 0.9, 1.2, 2.7, and 2.4% in the lumbar, femoral neck, Ward's triangle and trochanter area, respectively. Lumbar BMD was increased by 30% (P<0.001) in 15 patients with osteoarthritis (21% of women 50 years or older), but it was apparently unaffected in 5 cases with aortic calcification. Except for the trochanter area, BMD diminished along with age, and this was significant after the menopause. The peak of mean BMD was observed at the age of 31–35 years in the spine and at the age of 20–25 years in the femoral neck and Ward's triangle. BMD was in a positive relationship to weight both in premenopausal and postmenopausal women and to the use of oral contraceptives in premenopausal women and to that of estrogen replacement therapy in postmenopausal women. Labors and pregnancies had a weak positive effect on BMD in premenopausal women. As compared with nonusers premenopausal women who had used alcohol showed a slightly decreased BMD of Ward's triangle. In postmenopausal women there was a positive correlation between alcohol intake and BMD.

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References

  1. Simonen O (1986) Osteoporosis: a big challenge to public health. Calcif Tissue Int 39:295–296

    PubMed  CAS  Google Scholar 

  2. Avioli LV (1988) Socio-economic costs of osteoporosis and changing patterns. Ann Chir Gynaecol 77:168–172

    PubMed  CAS  Google Scholar 

  3. Cummings SR (1989) Epidemiology of osteoporotic fractures. Eur J Clin Invest 19:A85

    Google Scholar 

  4. Schroder HM (1989) Epidemiology of hip fractures in a Danish municipality. Eur J Clin Invest 19:A85

    Google Scholar 

  5. Mazess RB, Wahner HM (1988) Nuclear medicine and densitometry. In: Riggs BL, Melton III LJ (eds) Osteoporosis. Etiology, diagnosis and management. Raven Press, New York, p 261

    Google Scholar 

  6. Mazess R, Collick B, Trempe J, Barden H, Hanson J (1989) Performance evaluation of a dual-energy X-ray bone densitometer. Calcif Tissue Int 44:228–232

    PubMed  CAS  Google Scholar 

  7. Mazess RB, Barden HS (1988) Measurement of bone by dual-photon absorptiometry (DPA) and dual-energy X-ray absorptiometry (DEXA). Ann Chir Gynaecol 77:197–203

    PubMed  CAS  Google Scholar 

  8. Kelly TL, Slovik DM, Schoenfeld DA, Neer RM (1988) Quantitative digital radiography versus dual photon absorptiometry of the lumbar spine. J Clin Endocrinol Metab 67:839–844

    PubMed  CAS  Google Scholar 

  9. Pacifici R, Rupich R, Vered I, Fischer KC, Griffin M, Susman N, Avioli LV (1988) Dual-energy radiography (DER): a preliminary comparative study. Calcif Tissue Int 43:189–191

    PubMed  CAS  Google Scholar 

  10. Wahner HW, Dunn WL, Brown ML, Morin RL, Riggs BL (1988) Comparison of dual-energy X-ray absorptiometry and dual photon absorptiometry for bone mineral measurements of the lumbar spine. Mayo Clin Proc 63:1075–1084

    PubMed  CAS  Google Scholar 

  11. Strause L, Bracker M, Saltman P, Sartoris D, Kerr E (1989) A comparison of quantitative dual-energy radiographic absorptiometry and dual photon absorptiometry of the lumbar spine in postmenopausal women. Calcif Tissue Int 45:288–291

    PubMed  CAS  Google Scholar 

  12. Sartoris DJ, Resnick D (1989) Dual-energy radiographic absorptiometry for bone densitometry. Current status and perspective. AJR 152:241–246

    PubMed  CAS  Google Scholar 

  13. Genant HK, Steiger P, Glueer CC, Block JE (1989) Quantitative bone mineral assessment in osteoporosis. Eur J Clin Invest 19:A86

    Google Scholar 

  14. Riggs BL, Wahner HW, Dunn WL, Mazess RB, Offord KP, Melton III LJ (1981) Differential changes in bone mineral density of the appendicular and axial skeleton with aging. J Clin Invest 67:328–335

    PubMed  CAS  Google Scholar 

  15. Riggs BL, Wahner HW, Seeman E, Offord KP, Dunn WL, Mazess RB, Johnson KA, Melton III LJ (1982) Changes in bone mineral density of the proximal femur and spine with aging. J Clin Invest 70:716–723

    PubMed  CAS  Google Scholar 

  16. Riggs BL, Wahner HW, Melton III LJ, Richelson LS, Judd HL, Offord KP (1986) Rates of bone loss in the appendicular and axial skeletons of women. Evidence of substantial vertebral bone loss before menopause. J Clin Invest 77:1487–1491

    Article  PubMed  CAS  Google Scholar 

  17. Mazess RB, Barden HS, Ettinger M, Johnston C, Dawson-Hughes B, Baran D, Powell M, Notelovitz M (1987) Spine and femur density using dual-photon absorptiometry in US white women. Bone Miner 2:211–219

    Article  PubMed  CAS  Google Scholar 

  18. van Berkum FNR, Pols HAP, Kooij PPM, Birkenhäger JC (1988) Peripheral and axial bone mass in Dutch women. Relationship to age and menopausal state. Neth J Med 32:226–234

    PubMed  Google Scholar 

  19. Palummeri E, Girasole G, Davoli L, Bergonzani M, Pioli G, Meola P, Butturini L, Barbagallo M, Ciotti G, Pedrazzoni M (1987) Variazioni della massa ossea con l'età. Minerva Med 78:809–814

    PubMed  CAS  Google Scholar 

  20. Pocock NA, Eberl S, Eisman JA, Yeates MG, Sambrook PM, Freund J, Duncan A (1987) Dual-photon bone densitometry in normal Australian women: a cross-sectional study. Med J Aust 146:293–297

    PubMed  CAS  Google Scholar 

  21. Schaadt O, Bohr H (1988) Different trends of age-related diminution of bone mineral content in the lumbar spine, femoral neck, and femoral shaft in women. Calcif Tissue Int 42:71–76

    PubMed  CAS  Google Scholar 

  22. Stevenson JC, Lees B, Devenport M, Cust MP, Ganger KF (1989) Determinants of bone density in normal women: risk factors for future osteoporosis? Br Med J 298:924–928

    Article  CAS  Google Scholar 

  23. Liel Y, Edwards J, Shary J, Spicer KM, Gordon L, Bell NH (1988) The effects of race and body habitus on bone mineral density of the radius, hip, and spine in premenopausal women. J Clin Endocrinol Metab 66:1247–1250

    Article  PubMed  CAS  Google Scholar 

  24. Hansson T, Roos B (1986) Age changes in the bone mineral of the lumbar spine in normal women. Calcif Tissue Int 38:249–251

    Article  PubMed  CAS  Google Scholar 

  25. Ribot C, Tremollieres F, Pouilles J-M, Bonneu M, Germain F, Louvet J-P (1988) Obesity and postmenopausal bone loss: the influence of obesity on vertebral density and bone turn-over in postmenopausal women. Bone 8:327–331

    Article  Google Scholar 

  26. Dawson-Hughes B, Shipp C, Sadowski L, Dallal G (1987) Bone density of the radius, spine, and hip in relation to percent of ideal body weight in postmenopausal women. Calcif Tissue Int 40:310–314

    Article  PubMed  CAS  Google Scholar 

  27. Goldsmith NF, Johnston JO (1975) Bone mineral: effects of oral contraceptives, pregnancy and lactation. J Bone Joint Surg 57A:657–668

    Google Scholar 

  28. Bikle DD (1988) Effects of alcohol abuse on bone. Compr Ther 14(2):16–20

    PubMed  CAS  Google Scholar 

  29. Crilly RG, Anderson C, Hogan D, Delaquerriere-Richardson L (1988) Bone histomorphometry, bone mass, and related parameters in alcoholic males. Calcif Tissue Int 43:269–276

    Article  PubMed  CAS  Google Scholar 

  30. Bikle DD, Genant HK, Cann C, Recker RR, Halloran BP, Strewler GJ (1985) Bone disease in alcohol abuse. Ann Intern Med 103:42–48

    PubMed  CAS  Google Scholar 

  31. Dalen N, Lamke B (1976) Bone mineral losses in alcoholics. Acta Orthop Scand 47:469–471

    Article  PubMed  CAS  Google Scholar 

  32. Feitelberg S, Epstein S, Ismail F, D'Amanda C (1987) Deranged bone mineral metabolism in chronic alcoholism. Metabolism 36:322–326

    Article  PubMed  CAS  Google Scholar 

  33. Lalor BC, France MW, Powell D, Adams PH, Couninan TB (1986) Bone and mineral metabolism and chronic alcohol abuse. Q J Med 59:497–511

    PubMed  CAS  Google Scholar 

  34. Schnitzler CM, Solomon L (1984) Bone changes after alcohol abuse. S Afr Med J 66:730–734

    PubMed  CAS  Google Scholar 

  35. Spencer H, Rubio N, Rubio E, Indreika M, Seitam A (1986) Chronic alcoholism. Frequently overlooked cause of osteoporosis in men. Am J Med 80:393–397

    Article  PubMed  CAS  Google Scholar 

  36. de Vernejoul MC, Bielakoff J, Herve M, Gueris J, Hott M, Modrowski D, Kuntz D, Miravet L, Ryckewaert A (1983) Evidence for defective osteoblastic function. A role for alcohol and tobacco consumption in osteoporosis in middle-aged men. Clin Orthop 179:107–115

    PubMed  Google Scholar 

  37. Daniell HW (1976) Osteoporosis of the slender smoker: vertebral compression fractures and loss of metacarpal cortex in relation to postmenopausal smoking and lack of obesity. Arch Intern Med 136:298–304

    Article  PubMed  CAS  Google Scholar 

  38. Välimäki MJ, Härkönen M, Eriksson CJP, Ylikahri RH (1984) Sex hormones and adrenocortical steroids in men acutely intoxicated with ethanol. Alcohol 1:89–93

    Article  PubMed  Google Scholar 

  39. Gordon GG, Southren AL, Vittek J, Lieber CS (1979) The effect of alcohol ingestion on hepatic aromatase activity and plasma steroid hormones in the rat. Metabolism 28:20–24

    Article  PubMed  CAS  Google Scholar 

  40. Lindsay R (1988) Prevention and treatment of osteoporosis with ovarian hormones. Ann Chir Gyn 77:219–223

    CAS  Google Scholar 

  41. Lindsay R (1988) Sex steroids in the pathogenesis and prevention of osteoporosis. In: Riggs BL, Melton III LJ (eds) Osteoporosis. Etiology, diagnosis and management. Raven Press, New York, p 333

    Google Scholar 

  42. Civitelli R, Agnusdei D, Nardi P, Zacchei F, Avioli LV, Gennari C (1988) Effects of one-year treatment with estrogens on bone mass, intestinal calcium absorption, and 25-hydroxyvitamin D-1-alfa-hydroxylase reserve in postmenopausal osteoporosis. Calcif Tissue Int 42:77–86

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Research Unit of Alcohol Diseases, Helsinki University Central Hospital, Tukholmankatu 8 F, SF-00290, Helsinki, Finland

    Kalevi Laitinen

  2. Third Department of Medicine, University of Helsinki, Helsinki, Finland

    Matti Välimäki

  3. Department of Diagnostic Radiology, University of Helsinki, Helsinki, Finland

    Pekka Keto

  4. Helsinki Medical Center, Helsinki, Finland

    Kalevi Laitinen, Matti Välimäki & Pekka Keto

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  1. Kalevi Laitinen
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Laitinen, K., Välimäki, M. & Keto, P. Bone mineral density measured by dual-energy X-ray absorptiometry in healthy finnish women. Calcif Tissue Int 48, 224–231 (1991). https://doi.org/10.1007/BF02556372

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  • DOI: https://doi.org/10.1007/BF02556372

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