Summary
Patients with acute lymphatic leukaemia frequently are osteoporotic. A small subset of these develop disabling metaphyseal transverse fractures, usually bilateral and in the lower limb. These impaction fractures have a characteristic appearance and develop in recently laid down bone. They may develop ab initio or during therapy. Magnesium deficiency is found in these patients.
Similar content being viewed by others
References
Atkinson SA, Fraser D, Barr R, Pai M, Andrew M (1987) Abnormal mineral metabolism and bone mineralisation in children with acute lymphoblastic leukaemia during treatment. Clin Invest Med 10:A52
Baty JM, Vogt EC (1935) Bone changes of leukemia in children. AJR 34:310
Benz G, Brandeis WE, Willich E (1976) Radiological aspects of leukemia in childhood: an analysis of 89 children. Pediatr Radiol 4:206
Cohn SL, Morgan ER, Mallette LE (1987) The spectrum of metabolic bone disease in lymphoblastic leukemia. Cancer 59:346
Kalayjian BS, Herbut PA, Erf LA (1946) The bone changes of leukemia in children. Radiology 47:223
Parker B, Castellino R (1977) Pediatric oncologic radiology. Mosby, St. Louis, p 138
Pear BL (1974) Skeletal manifestations of the lymphomas and leukemias. Semin Roentgenol 9:229
Rogalsky RJ, Black GVB, Reed MH (1986) Orthopedic manifestation of leukemia in childhood. J Bone Joint Surg [Am] 68:494
Samuda GM, Cheng MY, Yeung CY (1987) Back pain and vertebral compression: an uncommon presentation of childhood acute lymphoblastic leukemia. J Pediatr Orthop 7:175
Silverman FN (1948) The skeletal lesions in leukemia: clinical and roentgenographic observations in 103 infants and children, with a review of the literature. AJR 59:819
Silverstein MN, Kelly PJ (1963) Leukemia with osteoarticular symptoms and signs. Ann Intern Med 59:637
Simmons CR, Harle TS, Singleton EB (1968) The osseous manifestations of leukemia in children. Radiol Clin North Am 6:115
Thomas LB, Forkner CE, Frei E, Besse BE, Stabenau JR (1961) The skeletal lesions of acute leukemia. Cancer 14:608
Willich E (1967) Quantitative Strukturverschiebungen in der Metaphyse des Säuglings aus klinisch-roentgenologischer und histologischer Sicht. Ann Radiol (Paris) 11:341
Schaerer VK, Uehlinger E, Hitzig W (1960) Spontanfrakturen mit Trümmerfeldzonen bei Paraleukoblastenleukämie. Helv Paediatr Acta 3:223
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Manson, D., Martin, R.F. & Cockshott, W.P. Metaphyseal impaction fractures in acute lymphoblastic leukemia. Skeletal Radiol. 17, 561–564 (1989). https://doi.org/10.1007/BF02569401
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF02569401