Skip to main content
SpringerLink
Log in

Hypereosinophilic syndrome

  • Clinical Brief
  • Published:
The Indian Journal of Pediatrics Aims and scope Submit manuscript

Abstract

Hyperreosinophilic syndrome is a leukoproliferative disease characterised by sustained overproduction of eosinophils. The three diagnostic criteria for this disorder are (1) Eosinophilia of greater than 1500 cells/ml, persisting for longer than 6 months, (2) lack of another diagnosis to explain the eosinophilia and (3) signs and symptoms of organ involvement. We report a 15-year-old boy who was diagnosed as Hypereosinophilic syndrome based on these criteria.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Chusid MJ, Dale DC, West BC, Wolff SM. The hypereosinophilic syndrome: analysis of fourteen cases with review of the literature.Medicine (Baltimore) 1975; 54: 1–27.

    Article  CAS  Google Scholar 

  2. Boxer LA. Hypereosinophilic syndrome. In Behrman RE, Kliegman RM, Jenson HB, eds.Nelson textbook of Pediatrics. 17th edn. Philadelphia; Saunders, 2004; 710.

    Google Scholar 

  3. Schooley RT, Flaum MA, Gralnick HR, Fauci AS. A clinicopathologic correlation of the idiopathic hypereosinophilic syndrome II. Clinical manifestations.Blood 1981; 58: 1021–1026.

    PubMed  CAS  Google Scholar 

  4. Alfaham MA, Ferguson SD, Sihra B, Davies J. The idiopathic hypereosinophilic syndrome.Arch Dis Child 1987; 62: 601–613.

    Article  PubMed  CAS  Google Scholar 

  5. Bain BJ. Eosinophilic leukemias and the idiopathic hypereosinophilic syndrome.Br J Haematol 1996; 95: 2–9.

    PubMed  CAS  Google Scholar 

  6. Roufosse F, Bartholome E, Schandene L, Goldman M, Cogan E. The idiopathic hypereosinophilic syndrome: Clinical presentation, pathogenesis and therapeutic strategies.Drugs Today (Barc) 1998; 34: 361–373.

    CAS  Google Scholar 

  7. Klion AD, Robyn J, Akin C, Noel P, Brown M, Law M, Metcalfe DD, Dunbar C, Nutman TB. Molecular remission and reversal of myelofibrosis in response to imatinib mesylate treatment in patients with myeloproliferative variant of hypereosinophilic syndrome.Blood 2004; 103: 473–478.

    Article  PubMed  CAS  Google Scholar 

  8. Klion AD, Law MA, Noel P, Kim YJ, Haverty TP, Nutman TB. Safety and efficacy of monoclonal anti interleukin 5 antibody SCH 55700 in the treatment of patients with hypereosinophilic syndrome.Blood 2004; 103: 2939–2941.

    Article  PubMed  CAS  Google Scholar 

  9. Juvonen E, Volin L, Koponen A, Ruutu T. Allogeneic blood stem cell transplantation following non-myeloablative conditioning for hypereosinophilic syndrome.Bone Marrow Transplantation 2002; 29: 457–458.

    Article  PubMed  CAS  Google Scholar 

  10. Takeda S, Takazakura E, Fukui Y. Tubulointerstitial nephritis in a patient with eosinophilic fasciitis and IgA nephropathy.Nephron 1995; 69: 314–317.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pediatrics, Pediatric Gastroenterology and Pediatric Nephrology, Kanchi Kamakoti CHILDS Trust Hospital, 600034, Chennai

    C. Venkatesh, E. Mahender, S. Janani (Senior Consultant), M. Vijayakumar & B. R. Nammalwar

Authors
  1. C. Venkatesh
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. Mahender
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. Janani
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S. Malathi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M. Vijayakumar
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. B. R. Nammalwar
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to S. Janani.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Venkatesh, C., Mahender, E., Janani, S. et al. Hypereosinophilic syndrome. Indian J Pediatr 73, 237–239 (2006). https://doi.org/10.1007/BF02825491

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02825491

Key words

Search

Navigation