Summary
Renal oncocytoma is a distinct type of epithelial tumor said to arise from the collecting duct system. Here we show that in nine of ten oncocytomas the tumor cells expressed an analog of the erythrocyte anion exchanger band 3. In the normal kidney band 3 is confined to the basolateral surface of the majority of intercalated cells which comprise up to 50% of the cortical collecting duct epithelium. Carbonic anhydrase c is another protein abundant in intercalated cells, and this was also expressed in six of the ten oncocytomas investigated. Immunoreactivity specific for band 3 and carbonic anhydrase c was not detected in any of the 20 renal cell carcinomas examined. At favourable section planes direct transitions between normal collecting ducts and oncocytic tubules were observed. These findings suggest that oncocytomas may develop from intercalated cells of the collecting duct epithelium.
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With support from the Deutsche Forschungsgemeinschaft (Sto 197/1-1 and Dr 91/5-2)
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Störkel, S., Pannen, B., Thoenes, W. et al. Intercalated cells as a probable source for the development of renal oncocytoma. Virchows Archiv B Cell Pathol 56, 185–189 (1988). https://doi.org/10.1007/BF02890016
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DOI: https://doi.org/10.1007/BF02890016