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An optical resolution of racemic organophosphorous esters by phosphotriesterase-catalyzing hydrolysis

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Conclusion

We have shown that PTE chiral recognition is limited to organophosphorous esters having the chiral center on the phosphorous atoms, which is attacked with nucleophile, not having the chiral center on the other atoms of the leaving group. Therefore, PTE can be utilized for the synthesis of their chiral organophosphorous esters.

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Authors and Affiliations

  1. Department of Biotechnology, Tokyo University of Agriculture and Technology, 2-24-16 Nakamachi, 184, Koganei, Tokyo, Japan

    Shokichi Ohuchi, Hiroyuki Nakamura, Hlroto Sligiura, Mltsuaki Narita & Koji Sode

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  1. Shokichi Ohuchi
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  2. Hiroyuki Nakamura
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  3. Hlroto Sligiura
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  4. Mltsuaki Narita
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  5. Koji Sode
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Ohuchi, S., Nakamura, H., Sligiura, H. et al. An optical resolution of racemic organophosphorous esters by phosphotriesterase-catalyzing hydrolysis. Appl Biochem Biotechnol 63, 659–665 (1997). https://doi.org/10.1007/BF02920464

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  • DOI: https://doi.org/10.1007/BF02920464

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