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Malignant B-cells have receptors for and respond to interleukin-2

  • Growth Factors and Hormones
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Abstract

Interleukin-2 (IL-2) for a long time has been considered as a T-cell specific growth factor which acts through distinct surface receptors present on activated, but not on resting, T-lymphocytes. Recently it has been shown that activated murine and human B-cells also express IL-2 receptors and respond to IL-2 with an increase of DNA synthesis. Some human B-cell malignancies have been reported to react with anti-IL-2 receptor antibodies, but no response to IL-2 has been documented in these cases. Here, in five of 11 B-cell leukemia/lymphoma cases, we identified cells which not only express the IL-2 receptor, but also respond to IL-2 stimulation, as shown by a marked increase of3H-thymidine incorporation and by differentiation of lymphoma cells. The IL-2-induced3H-thymidine uptake was completely blocked by a monoclonal antibody to IL-2 receptor, which indicates that IL-2 acted directly through functional IL-2 receptors.

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Authors and Affiliations

  1. Division of Hematology, Karolinska Hospital, Stockholm, Sweden

    Panos Panayotides, Anna Porwit & Peter Reizenstein

  2. Division of Immunology, National Bacteriological Laboratory, Stockholm, Sweden

    Rodica Lenkei

Authors
  1. Panos Panayotides
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  2. Rodica Lenkei
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  3. Anna Porwit
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  4. Peter Reizenstein
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Panayotides, P., Lenkei, R., Porwit, A. et al. Malignant B-cells have receptors for and respond to interleukin-2. Med. Oncol. & Tumor Pharmacother. 3, 255–263 (1986). https://doi.org/10.1007/BF02935002

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  • DOI: https://doi.org/10.1007/BF02935002

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