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Treatment of small cell lung cancer by eight weeks chemotherapy

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Abstract

Eighty-two patients with small cell lung cancer (SCLC), 32 with limited disease, were treated with alternating chemotherapy. Eight courses were administered at weekly intervals, and responding patients received radiotherapy to sites of bulk disease. Overall response rate was 76.8%. Overall median survival was 265 days, 408 days in patients with limited disease. The median symptom free period after chemotherapy was completed was 123 days. These results are comparable with those in reports of chemotherapy of longer duration and warrant the further investigation of short duration treatment in this disease.

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References

  1. Comis R L: Small cell carcinoma of the lung.Cancer Treat Rev 9, 237 (1982).

    Article  PubMed  CAS  Google Scholar 

  2. Slevin M L, Harvey V J, Ponder B A J,et al.: Small-cell lung carcinoma: survival after combination chemotherapy, radiotherapy or symptomatic treatment.Br J dis Chest 77, 381 (1983).

    Article  PubMed  CAS  Google Scholar 

  3. Smyth J F, Fowlie S M, Gregor A, Crompton G K, Busuttil A, Leonard R C F, Grant I W B: The impact of chemotherapy on small cell carcinoma of the bronchus.Quart J Med 61 969 (1986).

    PubMed  CAS  Google Scholar 

  4. Souhami R L, Harper P G, Linch D,et al.: High-dose cyclophosphamide with autologous marrow transplantation for small cell carcinoma of the bronchus.Cancer Chemother Pharmac 10, 205 (1983).

    CAS  Google Scholar 

  5. Osterlind K, Soerrenson S, Hansen H H,et al.: Continuous versus alternating chemotherapy for advanced small cell carcinoma of the lung.Cancer Res 43, 6085 (1983).

    PubMed  CAS  Google Scholar 

  6. Daugaard G, Hansen H H, Rorth M: Phase II study of vindesine, cisplatin and hexamethylmelamine (VCH) in small cell carcinoma of the lung.Cancer Treat Rep 68, 1179 (1984).

    PubMed  CAS  Google Scholar 

  7. Lowenbraun S, Birch R, Buchanan R: Combination chemotherapy in small cell lung carcinoma. A randomised study of two regimens.Cancer 54, 2344 (1984).

    Article  PubMed  CAS  Google Scholar 

  8. Klastersky J: Therapy of small cell lung cancer: anything new?Eur J Cancer clin Oncol 24, 107 (1988).

    Article  PubMed  CAS  Google Scholar 

  9. World Health Authority:WHO Handbook for Reporting the Results of Cancer Treatment. WHO Offset Publication No 48. WHO, Geneva (1979).

    Google Scholar 

  10. Carroll K B, Moussalli H, Brown D, Thatcher N: A comparison between a single agent short course chemotherapy regimen and a quadruple prolonged course regimen for small cell bronchogenic cancer.Br J Dis Chest 77, 171 (1983).

    Article  PubMed  CAS  Google Scholar 

  11. Johnson D H, Einhorn L H, Birch R, Vollmer R, Perez C, Krauss S, Omura G, Greco F A: A randomized comparison of high dose versus conventional dose cyclophosphamide, doxorubicin and vincristine for extensive-stage small-cell lung cancer: a phase III trial of the southeastern cancer study group.J clin Oncol 11, 1731 (1987).

    Google Scholar 

  12. Humblet Y, Symann M, Bosly A, Delaunois L, Francis C, Machiels J, Beauduin M, Doyen C, Weynants P, Longueville J, Prignot J: Late intensification therapy with autologous bone marrow transplantation in selected small-cell carcinoma of the lung: a randomised study.J clin Oncol 5, 1864 (1987).

    PubMed  CAS  Google Scholar 

  13. Kessinger A, Foley J F, Lemon H M: Therapeutic management of small cell lung cancer.J Am Med Ass 250, 3188 (1983).

    Article  CAS  Google Scholar 

  14. Morgan D A L, Gilson D, Fletcher J: Vincristine and etoposide: an effective chemotherapy regimen with reduced toxicity in extensive small cell lung cancer.Eur J Cancer clin Oncol 23, 619 (1987).

    Article  PubMed  CAS  Google Scholar 

  15. Thatcher N, James R D, Steward W P,et al.: Three months treatment with cyclophosphamide, VP16-213 followed by methotrexate and thoracic radiotherapy for small cell lung cancer.Cancer 56, 1332 (1985).

    Article  PubMed  CAS  Google Scholar 

  16. Thatcher N, Stout R, Smith D B,et al.: Three months chemotherapy and radiotherapy for small cell lung cancer.Br J Cancer 52, 327 (1985).

    PubMed  CAS  Google Scholar 

  17. Spiro S G, Souhami R L, Ash C M,et al.: Randomised trial of planned versus as required chemotherapy in small cell lung cancer.Lung Cancer 4 (suppl.), A101 (1988).

    Google Scholar 

  18. Geddes D M, Law K S, Spiro S G,et al.: Quality of life in small cell carcinoma of the lung: a comparison of two chemotherapy regimes using daily diary cards.Lung Cancer 4 (suppl.), A182 (1988).

    Google Scholar 

  19. Evans W K, Feld R, Osoba D, Shepherd F A, Dill J, Deboer G: VP16 alone and in combination with cisplatin in previously treated patients with small cell lung cancer.Cancer 53, 1461 (1984).

    Article  PubMed  CAS  Google Scholar 

  20. Lopez J A, Mann J, Grapski R T: Etoposide and cisplatin salvage chemotherapy for small cell lung cancer.Cancer Treat Rep 69, 369 (1985).

    PubMed  CAS  Google Scholar 

  21. Goldie J H, Coldman A J: A mathematical model for relating the drug sensitivity of tumours to their spontaneous mutation rate.Cancer Treat Rep 63, 1727 (1979).

    PubMed  CAS  Google Scholar 

  22. Daniels J R, Chak L Y, Sikic B I,et al.: Chemotherapy of small-cell carcinoma of lung: a randomised comparison of alternating and sequential combination chemotherapy programs.J clin Oncol 2, 1192 (1984).

    PubMed  CAS  Google Scholar 

  23. Cantwell B M J, Bozzino J M, Corris P, Harris A L: The multidrug resistant phenotype in clinical practice; evaluation of cross resistance to ifosfamide and mesna after VP16-213, doxorubicin and vincristine (VPAV) for small cell lung cancer.Eur J Cancer clin Oncol 24, 123 (1988).

    Article  PubMed  CAS  Google Scholar 

  24. Souhami R L, Geddes D M, Spiro S G,et al.: Radiotherapy in small cell cancer of the lung treated with combination chemotherapy: a controlled trial.Br Med J 288, 1643 (1984).

    Article  CAS  Google Scholar 

  25. Perez C A, Einhorn L, Oldham R K,et al.: Randomized trial of radiotherapy to the thorax in limited small cell carcinoma of the lung treated with multiagent chemotherapy and elective brain irradiation: a preliminary report.J clin Oncol 2, 1200 (1984).

    PubMed  CAS  Google Scholar 

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Crawford, S.M., Parker, D., Glaser, M.G. et al. Treatment of small cell lung cancer by eight weeks chemotherapy. Med. Oncol. & Tumor Pharmacother. 6, 279–283 (1989). https://doi.org/10.1007/BF02985162

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  • DOI: https://doi.org/10.1007/BF02985162

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