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Temporal changes in superoxide dismutase, glutathione peroxidase, and catalase levels in primary and peri-ischemic tissue

Monosialoganglioside (GM1) treatment effects

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Molecular and Chemical Neuropathology

Abstract

Time-dependent changes in levels of the antioxidant enzymes, superoxide dismutasae (SOD), glutathione peroxidase (GSHPOD), and catalase (CAT) after cortical focal ischemia in rat indicate that: (1) primary and peri-ischemic tissues differ in both rate and the magnitude of oxyradical-induced ischemic injury, and (2) ischemic tissue remains vulnerable to oxyradical damage as long as 72 h after ischemia since the antioxidant enzyme levels remain at or below basal levels. After 72h, the increased levels of these enzymes are sufficient to protect tissue against oxyradical damage. GM1 ganglioside (10 mg/kg, im) further increased the already elevated levels of the enzymes after ischemia, thereby indicating the GM1 treatment increases the capacity of ischemic tissue to protect against oxyradical injury.

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  1. Sahebarao P. Mahadik

    Present address: Department of Psychiatry and Health Behavior, Medical College of Georgia, 30912, Augusta, GA

Authors and Affiliations

  1. Division of Neuroscience, New York State Psychiatric Institute, New York

    Sahebarao P. Mahadik, Tapas K. Makar, Jayasimha N. Murthy, Astrid Ortiz, Chandramohan G. Wakade & Steven E. Karpiak

  2. Departments of Psychiatry, Biochemistry and Molecular Biophysics, College of Physicians and Surgeons, Columbia University, New York

    Sahebarao P. Mahadik & Steven E. Karpiak

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  1. Sahebarao P. Mahadik
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Mahadik, S.P., Makar, T.K., Murthy, J.N. et al. Temporal changes in superoxide dismutase, glutathione peroxidase, and catalase levels in primary and peri-ischemic tissue. Molecular and Chemical Neuropathology 18, 1–14 (1993). https://doi.org/10.1007/BF03160018

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  • DOI: https://doi.org/10.1007/BF03160018

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