Abstract
The lack of efficiency of classical treatments for obesity has led to propose alternative strategies. In order to obtain information about the effects of dietary fatty acid composition on body fat and protein metabolism, overweight female rats were fed on isoenergetic diets, using either medium-chain (MCT) or long-chain (LCT) triglycerides as a lipid source. After 23 days, the MCT group had mildly decreased body weight but greatly reduced adipose tissue depots. All fat depots were significantly diminished. MCT-fed rats showed a decrease in some hormones involved in energy balance, such as leptin and triiodothyronine. Feeding MCT resulted in improvements in nitrogen balance. Muscle protein content was similar in both treatments despite an increase in protein degradation in the MCT group. The present data clearly show that a diet with MCT as lipid fuel depresses weight gain and fat stores, relative to a standard LCT diet.
Resumen
La falta de eficacia de las dietas tradicionales en el tratamiento de la obesidad ha llevado a proponer estrategias alternativas. Con el objetivo de obtener información en ácidos grasos de la dieta sobre la grasa corporal y el metabolismo proteico, se alimentan ratas hembra con sobrepeso con dietas isoenergéticas que contienen triglicéridos con ácidos grasos de cadena media (MCT) o larga (LCT) como fuente lipídica. Tras 23 días, el grupo MCT muestra un descenso en el peso corporal junto con una importante reducción del depósito lipídico. Todas las localizaciones adiposas estudiadas se reducen significativamente. Este grupo MCT presenta menor concentración de algunas hormonas implicadas en el balance energético, tales como la leptina y la triyodotironina. La alimentación con MCT consigue mejora en el balance de nitrógeno. El contenido proteico muscular resulta similar en ambos grupos, aunque el grupo MCT muestra una mayor degradación proteica. Estos resultados muestran claramente que una dieta con MCT como fuente lipídica, frente a una dieta con LCT, reduce los depósitos grasos, ralentizando la ganancia de peso.
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References
Ali Qureshi, G., Gutiérrez, A. and Bergström, J. (1986):J. Chromatogr.,374, 363–369.
Andersen, R. E., Wadden, T. A., Bartlett, S. J., Vogt, R. A. and Weinstock, R. S. (1995):Am. J. Clin. Nutr.,62, 350–357.
Bach, A. C. and Babayan, V. K. (1982):Am. J. Clin. Nutr.,36, 950–962.
Bach, A. C., Ingenbleek, Y. and Frey, A. (1996):J. Lip. Res.,37, 708–726.
Bach, A. C., Weryha, A. and Schirardin, H. (1979):Ann. Biol. Anim. Biochim. Biophys.,19, 625–635.
Bell, R. R., Spencer M. J. and Sheriff, J. L. (1995):J. Nutr.,125, 2356–2363.
Binnert, C., Pachiaudi, C., Beylot, M., Hans, D., Vandermander, J., Chantre, P., Riou, J. P. and Laville, M. (1998):Am. J. Clin. Nutr.,67, 595–601.
Bray, G. A., Lee, M. and Bray, T. L. (1980):Int. J. Obes.,4, 27–32.
Chanez, M., Bois-Joyeux, B., Arnaud, M. J. and Peret, J. (1991):J. Nutr.,121, 585–594.
Crozier, G. L. (1988):J. Nutr.,18, 297–304.
Cynober, L. (1989):JPEN,13, 193–205.
Del Barrio, A. S., García-Calonge, M. A., Fernández-Quintela, A., Simón, E., Portillo, M. P., Astiasarán, I. and Martínez, J. A. (1995):Ann. Nutr. Metab.,39, 317–324.
Del Barrio, A. S., Rodríguez-Mariscal, M., Martínez, J. A. and Larralde, J. (1992):Growth Develop. Aging,56, 141–148.
Dulloo, A. G., Fathi, M., Mensi, M. and Giradier, L. (1996):Eur. J. Clin. Nutr.,50, 152–158.
Dulloo, A. G. (1997):Clin. Nutr.,16, 25–35.
Fearon, V. R. (1939):Biochem. J.,43, 305–310.
Featherson, W. R., Bird, H. R. and Harper, A. E. (1963):J. Nutr.,78, 198–206.
Geliebter, A., Torbay, N., Bracco, E. F., Hashim, A. A. and Van Itallie, T. B. (1983):Am. J. Clin. Nutr.,37, 1–4.
Georgi, G., Pietsch, C. and Sawatzki, G. (1993):J. Chromatogr.,613, 35–42.
Hardie, L. J., Rayner, D. V., Holmes, S. and Trayhurn, P. (1996):Biochem. Biophys. Res. Commun.,223, 660–665.
Häussinger, D. and vom Dahl, S. (1995): In “Amino acid Metabolism and Therapy in Health and Nutritional Disease” (L. A. Cynober, ed.). CRC press, Boca Raton. pp. 167–177.
Hwang, S. G., Yano, H. and Kawashima, R. (1993):J. Am. Coll. Nutr.,2, 643–650.
Jackson, A. A. (1993):Proc. Nutr. Soc.,52, 1–10.
Lavau, M. and Hashim, S. A. (1978):J. Nutr.,108, 613–620.
Lladó, I., Picó, C., Palou, A. and Pons, A. (1995):Physiol. Behav.,58, 513–519.
Lowry, O. H., Rosebrougth, N. H., Farr, A. L. and Randall, R. (1951):J. Biol. Chem.,193, 265–275.
Martínez, J. A., Aguado, M. and Frühbeck, G. (2000):J. Physiol. Biochem.,56, 1–8.
Munro, H. N. and Fleck, J. (1966):Analyst,9, 78–84.
Nakamura, T., Yoshihara, D., Ohmori, T., Yanai, M. and Takeshita, Y. (1994):J. Nutr. Sci. Vitaminol.,40, 147–159.
Nijveldt, R. J., Tan, A. M., Prins, H. A., DeJong, D., VanRij, G. L., Wesdorp, R. I. C. and VanLeeuwen, P. A. M. (1998):Clin. Nutr.,17, 23–29.
Papamandjaris, A. A., White, M. D., Raeini-Sarjaz, M. and Jones, P. J. H. (2000):Int. J. Obes.,24, 1158–1166.
Portillo, M. P., Serra, F., Simón, E., Del Barrio, A. S. and Palou, A. (1998):Int. J. Obes.,22, 974–979.
Rayner, D. V., Simón, E., Duncan, J. and Trayhurn, P. (1998):FEBS Lett.,429, 395–398.
Reeves, P. G., Nielsen, F. H. and Fahey, G. C. (1993):J. Nutr.,123, 1939–1951.
Rolls, B. J., Gnizak, N., Summerfelt, A. and Laster, L. J. (1988):Am. J. Clin. Nutr.,48, 66–71.
Rothwell, N. J. and Stock, M. J. (1987):Metabolism,36, 128–130.
Scalfi, L., Coltorti, A. and Contaldo, F. (1991):Am. J. Clin. Nutr.,53, 1130–1133.
Serra, F., Picó, C., Jonston, J., Carnie, J. and Palou, A. (1993):Biochem. Mol. Biol. Int.,29, 483–491.
Simón, E., Del Barrio, A. S., Serra, F., Palou, A. and Portillo, M. P. (1998):Rep. Nutr. Dev.,38, 193.
Stubbs, R. J. and Harbron, C. G. (1996):Int. J. Obes.,20, 435–444.
Swift, L. L., Hill, J. O., Peters, J. C. and Greene, H. L. (1990):Am. J. Clin. Nutr.,52, 834–836.
Takada, R. and Saitoh, M. (1995):J. Nutr. 125, 2165–2171.
Takase, S., Morimoto, A., Nakanishi, M. and Muto, Y. (1977):J. Nutr. Sci. Vitaminol.,23, 43–51.
Trayhurn, P., Hoggard, N., Mercer, J. G. and Rayner, D. V. (1999):Int. J. Obes.,23, 22–28.
Tremblay, A. (1995):Int. J. Obes.,19, 10–14.
Trinder, P. (1969):Ann. Clin. Biochem.,6, 24–27.
Van Loan, M. D., Belko, A. Z., Mayelin, P. L. and Barbieri, T. F. (1987):Am. J. Clin. Nutr.,46, 5–8.
Van Wymelbeke, V., Himaya, A., Louis-Sylvestre, J. and Fantino, M. (1998):Am. J. Clin. Nutr.,68, 226–234.
Young, V. R., Marchini, J. S. and Cortiella, J. (1990):J. Nutr.,120, 1496–1502.
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Simón, E., Fernández-Quintela, A., Del Puy Portillo, M. et al. Effects of medium-chain fatty acids on body composition and protien metabolism in overweight rats. J. Physiol. Biochem. 56, 337–346 (2000). https://doi.org/10.1007/BF03179802
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DOI: https://doi.org/10.1007/BF03179802