Summary
Six beagles received intravenous and oral doses of 50 mg/kg phenacetin. Plasma concentrations of phenacetin, paracetamol, andp-phenetidin were determined and pharmacokinetic parameters calculated.
Phenacetin showed rate constants for absorption and elimination of 0.025 and 0.033 (min−1) and an apparent metabolic clearance rate of about 350 ml/min. Paracetamol andp-phenetidin elimination rate constants were 0.02 and 0.015 (min−1), respectively.
There was no difference in pharmacokinetics or metabolic pattern between both routes of phenacetin administration.
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Souchay, S., Wörner, A., Kampffmeyer, H.G. et al. Comparison of the pharmacokinetics of phenacetin in beagles after oral or intravenous administration. European Journal of Drug Metabolism and Pharmacokinetics 1, 21–24 (1976). https://doi.org/10.1007/BF03192275
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DOI: https://doi.org/10.1007/BF03192275