Abstract
We report the unusual occurrence of a neuroendocrine prostatic tumor in two young males with multiple endocrine neoplasia (MEN) 2B. Immunohistochemistry of the tumor markers may help differentiate a primary neuroendocrine prostate tumor from the metastasis of a medullary thyroid carcinoma of poor prognosis. MEN 2B hallmarks (i.e. plasma thyrocalcitonin and urinary metanephrines) may be systematically investigated in neuroendocrine tumors of the prostate, and conversely prostate examination may be performed in the periodic screening of MEN 2B male patients.
Similar content being viewed by others
References
Whelan T, Gatfield CT, Robertson S, Carpenter B, Schillinger JF. Primary carcinoid of the prostate in conjunction with multiple endocrine neoplasia IIb in a child. J Urol 1995, 153: 1080–2.
Bravo EL. Pheochromocytoma: New concepts and future trends. Kidney Int 1991, 40: 544.
Duh QY, Hybarger CP, Geist R, et al. Carcinoids associated with multiple endocrine neoplasia syndroms. Am J Surg 1987, 154: 142–8.
Zrara I, Al Bouzidi A, Rimani M, Touiti D, Labraimi A, Ben Omar S. Le carcinome à petites cellules de la prostate. A propos d’un cas. J Urol (Paris) 1996, 102: 188–90.
Okada H, Gotoh A, Ogawa T, Arakawa S, Ohbayashi C, Kamidono S. Two cases of small cell carcinoma of the prostate. Scand J Urol Nephrol 1996, 30: 503–8.
Di Sant’Agnese PA. Neuroendocrine differentiation in carcinoma of prostate: diagnostic, prognostic, and therapeutic implications. Cancer 1992, 70: 254–68.
Shapiro B, Gonzales E, Weissman A, McHugh T, Markel SF. Malignant paraganglioma of the prostate: case report, depiction by meta-iodobenzylguanidine scintigraphy and review of the literature. Q J Nucl Med. 1997, 41: 36–41.
Hasselager T, Horn T, Rasmussen F. Paraganglioma of the prostate. A case report and review of the literature. Scand J Urol Nephrol. 1997, 31: 501–3.
Abrahamsson PA, Wadstrom LB, Alumets J. Peptide-hormone and serotonin-immunoreactive cells in normal and hyperplastic prostate glands. Pathol Res Pract 1986, 181: 675–83.
Abrahamsson PA. Neuroendocrine cells in tumour growth of the prostate. Endocr Relat Cancer 1999, 6: 503–19.
Ro JY, Tetu B, Ayala AG, Ordonez NG. Small cell carcinoma of the prostate. II. Immunohistochemical and electron microscopic studies of 18 cases. Cancer 1987, 59: 977–82.
Di Sant’Agnese PA. Calcitonin-like immunoreactive and bombesin-like immunoreactive endocrine-paracrine cells of the human prostate. Arch Pathol Lab Med 1986, 110: 412–15.
Fetissof F, Bertrand G, Guilloteau D. Calcitonin immunoreactive cells in prostate gland and cloacal derived tissues. Virchows Arch A Pathol Anat Histopathol 1986, 409: 523–33.
Di Sant’Agnese PA, De Mesy Jensen KL. Somatostatin and/ or somatostatin-like immunoreactive endocrine-paracrine cells in the human prostate gland. Arch Pathol Lab Med 1984, 108: 693–96.
Di Sant’Agnese PA, De Mesy Jensen KL. Calcitonin, katacalcin and calcitonin gene-related peptide in the human prostate: An immunocytochemical and immunoelectron microscopic study. Arch Pathol Lab Med 1989, 113: 790.
Abrahamsson PA, Lilja H. Partial characterization of a thyroidstimulating hormone-like peptide in neuroendocrine cells of the human prostate gland. Prostate 1989, 14: 71–81.
Schron DS, Gipson Mendelsohn G. The histogenesis of small cell carcinoma of the prostate: An immunohistochemical study. Cancer 1984, 53: 2478–80.
Sandhu SS, Denton A, Jarmulowicz M, Pigott K, Kaisary AV. Pure small cell carcinoma of the prostate. Clin Oncol 1997, 9: 412–4.
Di Sant’Agnese A. Neuroendocrine differentiation in human prostatic carcinoma. Hum Pathol 1992, 23: 287–96.
Sim SJ, Glassman AB, Ro JY, Lee JJ, Logothesis CJ, Liu FJ. Serum calcitonin in small cell carcinoma of the prostate. Ann Clin Lab Sci 1996, 26: 487–95.
Lazzaro D, Price M, De Felice M, Di Lauro R. The transcription factor TTF-1 is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of the fetal brain. Development 1991, 113: 1093–104.
Katoh R, Miyagi E, Nakamura N, et al. Expression of thyroid transcription factor-1 (TTF-1) in human C cells and medullary thyroid carcinomas. Hum Pathol 2000, 31: 386–93.
Pretl K. Zur Frage der Endokrinie der menschlichen Vorsteherdruse. Virchows Arch A Pathol Anat Histopathol 1944, 312: 392–404.
Di Sant’Agnese PA, De Mesy Jensen KL, Churukian CJ, Agarwal MM. Human prostatic endocrine-paracrine (APUD) cells: Distributional analysis with a comparison of serotonin and neuron-specific enolase immunoreactivity and silver stains. Arch Pathol Lab Med 1985, 109: 607–12.
Bejarano PA, Baughman RP, Biddinger PW, et al. Surfactant proteins and thyroid transcription factor-1 in pulmonary and breast carcinomas. Mod Pathol 1996, 9: 445–52.
Holzinger A, Dingle S, Bejarano PA, et al. Monoclonal antibody to thyroid transcription factor-1: production, characterization, and usefulness in tumor diagnosis. Hybridoma 1996, 15: 49–53.
Bejarano PA, Nikiforov YE, Swenson ES, Biddinger PW. Thyroid transcription factor-1, thyroglobulin,cytokeratin 7 and cytokeratin 20 in thyroid neoplasms. Appl Immunohistochem Molecul Morphol 2000, 8: 189–94.
Ros P, Rossi DL, Acebron A, Santisteban P. Thyroid-specific gene expression in the multi-step process of thyroid carcinogenesis. Biochimie 1999, 81: 389–96.
Agoff SN, Lamps LW, Philip AT, et al. Thyroid transcription factor-1 is expressed in extrapulmonary small cell carcinomas but not in other extrapulmonary neuroendocrine tumors. Mod Pathol 2000, 13: 238–42.
Cheuk W, Kwan MY, Suster S, Chan JK. Immunostaining for thyroid transcription factor 1 and cytokeratin 20 aids the distinction of small cell carcinoma from Merkel cell carcinoma, but not pulmonary from extrapulmonary small cell carcinomas. Arch Pathol Lab Med 2001, 125: 228–31.
Ordonez NG. Value of thyroid transcription factor-1 immunostaining in distinguishing small cell lung carcinomas from other small cell carcinomas. Am J Surg Pathol 2000, 24: 1217–23.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Goulet-Salmon, B., Berthe, E., Franc, S. et al. Prostatic neuroendocrine tumor in multiple endocrine neoplasia Type 2B. J Endocrinol Invest 27, 570–573 (2004). https://doi.org/10.1007/BF03347481
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF03347481