Abstract.
Objective:
To identify the differences in cytokine profile between allogeneic and syngeneic pregnancy in mice with collagen-induced arthritis (CIA).
Methods:
Mice (strain B10.RIII) were injected with bovine collagen. Females were mated with males of the same strain (syngeneic pregnancy) or with males of strain B10. Q (allogeneic pregnancy). Concentrations of cytokines were measured during pregnancy and after delivery, and the onset and evolution of arthritis was followed in all female animals throughout the study period.
Results:
In female mice that developed CIA, cytokine concentrations were lower in allogeneic pregnancies than syngeneic pregnancies. When paired cytokine concentrations were compared in each animal during and after pregnancy, MCP-1 was lower during gestation than after delivery in both groups of pregnant mice, IL-6 was lower during gestation than after delivery only in allogeneic pregnancies, and IL-10 was lower during gestation than after delivery in allogeneic pregnancies, whereas in syngeneic pregnancies IL-10 was higher during gestation than after delivery.
Conclusions:
Allogeneic pregnancy was associated with less arthritis because of lower concentrations of proinflammatory cytokines (IL-6 and others), not because of an increase in the concentration of antiinflammatory cytokines (IL-10).
Similar content being viewed by others
Author information
Authors and Affiliations
Corresponding author
Additional information
Received 21 October 2007; returned for revision 12 November 2007; received from final revision 5 December 2007; accepted by J. Di Battista 13 December 2007
Rights and permissions
About this article
Cite this article
González, D.A., de León, A.C., Moncholi, C.V. et al. Cytokine profile in collagen-induced arthritis: Differences between syngeneic and allogeneic pregnancy. Inflamm. res. 57, 266–271 (2008). https://doi.org/10.1007/s00011-007-7197-9
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00011-007-7197-9