Abstract
Objective
Histamine derived from mast cells and basophils plays important roles in inducing allergic symptoms. Although T cells also produce histamine, the involvement of the histamine produced from T cells has remained enigmatic. We sought to reveal the roles of T helper 2 (Th2) cell-derived histamine in nasal allergic disorders.
Methods
The histamine production from Th2 cells was measured by EIA. The mRNA expression of histidine decarboxylase (HDC) was measured by real-time PCR. To investigate the roles of Th2 cell-derived histamine in vivo, we analyzed an antigen-specific Th2 cell transfer mouse model.
Results
Th2 cells produced histamine by T cell receptor stimulation, and these properties were specific for Th2 cells, but not Th1 cells and naïve CD4 T cells. The histamine produced from Th2 cells was involved in the infiltrations of Th2 cells in response to antigen exposure.
Conclusion
These results suggest that Th2 cell-derived histamine play important roles in nasal allergic disorders.
References
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Iwasaki N, Matsushita K, Fukuoka A, Nakahira M, Matsumoto M, Akasaki S, et al. Allergen endotoxins induce T-cell-dependent and non-IgE-mediated nasal hypersensitivity in mice. J Allergy Clin Immunol. 2017;139(1):258-68.e10.
Iwasaki N, Terawaki S, Shimizu K, Oikawa D, Sakamoto H, Sunami K, et al. Th2 cells and macrophages cooperatively induce allergic inflammation through histamine signaling. PLoS ONE. 2021. https://doi.org/10.1371/journal.pone.0248158.
Acknowledgements
This work was supported by a Japan Society for the Promotion of Science KAKENHI Grant-in-Aid for Young Scientists (Grant Number 19K17912) to N.I. and a GlaxoSmithKline Japan Research Grant 2017 to N.I.
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Iwasaki, N., Terawaki, S., Shimizu, K. et al. Th2 cell-derived histamine is involved in nasal Th2 infiltration in mice. Inflamm. Res. 70, 539–541 (2021). https://doi.org/10.1007/s00011-021-01458-x
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DOI: https://doi.org/10.1007/s00011-021-01458-x