Abstract
The classical view that endogenous antigens are processed by the proteasome and loaded on MHC class I molecules in the endoplasmic reticulum, while exogenous antigens taken up by endocytosis or phagocytosis are degraded and loaded on MHC class II in lysosome-derived organelles, has evolved along with the improvement of our understanding of the cell biology of antigen-presenting cells. In recent years, evidence for alternative presentation pathways has emerged. Exogenous antigens can be processed by the proteasome and loaded on MHC class I through a pathway called cross-presentation. Moreover, endogenous antigens can be targeted to lytic organelles for presentation on MHC class II through autophagy, a highly conserved cellular process of self-eating. Recent evidence indicates that the vacuolar degradation of endogenous antigens is also beneficial for presentation on MHC class I molecules. This review focuses on how various forms of autophagy participate to presentation of these antigens on MHC class I.
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M. Chemali and K. Radtke contributed equally to this work.
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Chemali, M., Radtke, K., Desjardins, M. et al. Alternative pathways for MHC class I presentation: a new function for autophagy. Cell. Mol. Life Sci. 68, 1533–1541 (2011). https://doi.org/10.1007/s00018-011-0660-3
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DOI: https://doi.org/10.1007/s00018-011-0660-3