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Interkinetic nuclear migration: beyond a hallmark of neurogenesis

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Abstract

Interkinetic nuclear migration (INM) is an oscillatory nuclear movement that is synchronized with the progression of the cell cycle. The efforts of several researchers, following the first report of INM in 1935, have revealed many of the molecular mechanisms of this fascinating phenomenon linking the timing of the cell cycle and nuclear positioning in tissue. Researchers are now faced with a more fundamental question: is INM important for tissue, particularly brain, development? In this review, I summarize the current understanding of the regulatory mechanisms governing INM, investigations involving several different tissues and species, and possible explanations for how nuclear movement affects cell-fate determination and tissue formation.

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Acknowledgments

The author thanks Drs. Akatsuki Kimura (Mishima), Takaki Miyata (Nagoya), and Caren Norden (Dresden) for their critical readings and helpful comments on the manuscript. I thank Dr. Kazunori Toida and the Electron Microscopy Research Center in Kawasaki Medical School for their technical support. Y. Kosodo was supported by research grants from the Japan Society for the Promotion of Science, Takeda Science Foundation, Novartis Foundation, Okayama Medical Foundation, and Kawasaki Medical School (23C-1).

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  1. Department of Anatomy, Kawasaki Medical School, 577 Matsushima, Kurashiki, 701-0192, Japan

    Yoichi Kosodo

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Kosodo, Y. Interkinetic nuclear migration: beyond a hallmark of neurogenesis. Cell. Mol. Life Sci. 69, 2727–2738 (2012). https://doi.org/10.1007/s00018-012-0952-2

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