Abstract
Pest insect species are a burden to humans as they destroy crops and serve as vectors for a wide range of diseases including malaria and dengue. Chemical insecticides are currently the dominant approach for combating these pests. However, the de-registration of key classes of chemical insecticides due to their perceived ecological and human health risks in combination with the development of insecticide resistance in many pest insect populations has created an urgent need for improved methods of insect pest control. The venoms of arthropod predators such as spiders and scorpions are a promising source of novel insecticidal peptides that often have different modes of action to extant chemical insecticides. These peptides have been optimized via a prey–predator arms race spanning hundreds of millions of years to target specific types of insect ion channels and receptors. Here we review the current literature on insecticidal venom peptides, with a particular focus on their structural and pharmacological diversity, and discuss their potential for deployment as insecticides.
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Abbreviations
- 3D:
-
Three-dimensional
- BKCa :
-
Maxi-K calcium-activated potassium channel
- CaV :
-
Voltage-gated calcium channel
- CSα/β:
-
Cystine-stabilized α/β
- DDH:
-
Disulfide-directed β-hairpin
- DmNaV :
-
Drosophila voltage-gated sodium channel
- GABA:
-
γ-aminobutyric acid
- HVA:
-
High-voltage activated
- HXTX:
-
Hexatoxin
- ICK:
-
Inhibitor cystine knot
- KV :
-
Voltage-gated potassium channel
- MATP:
-
Myoactive tetradecapeptide
- NaV :
-
Voltage-gated sodium channel
- LVA:
-
Low-voltage activated
- MVA:
-
Mid-voltage activated
- nAChR:
-
Nicotinic acetylcholine receptor
- NMDA:
-
N-methyl-d-aspartic acid
- RyR:
-
Ryanodine receptor
- TRTX:
-
Theraphotoxin
- tLVA:
-
Transient low-voltage activated
- TTX-R:
-
Tetrodotoxin-resistant
- TTX-S:
-
Tetrodotoxin-sensitive
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Smith, J.J., Herzig, V., King, G.F. et al. The insecticidal potential of venom peptides. Cell. Mol. Life Sci. 70, 3665–3693 (2013). https://doi.org/10.1007/s00018-013-1315-3
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DOI: https://doi.org/10.1007/s00018-013-1315-3